Comparative Effectiveness of Antibiotic Prophylaxis of Postoperative Complications After Transurethral Resection of the Prostate
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
Benign prostatic hyperplasia (BPH) is one of the most common benign diseases in men, as it leads to an enlarged prostate, the development of lower urinary tract symptoms, and worsens the quality of patient’s life. Surgical treatment is indicated to patients after non-effective drug treatment. Most often, transurethral resection of the prostate (TURP) is used.
The objective: to improve the results of TURP in patients with BPH and acute urinary retention by optimizing antibacterial prophylaxis of postoperative complications in the early postoperative period.
Materials and methods. An analysis of the surgical treatment of 179 patients with BPH with acute urinary retention after TURP was performed. The age of the patients varied from 51 to 84 years old, the average age was 64.9±5.1 years. All patients had a complex urological examination in the preoperative period. The patients were divided into two groups: I group – 85 patients after operation who were prescribed ceftriaxone in the early postoperative period; II group – 94 patients who received levofloxacin in the early postoperative period.
Results. It was determined that complications occurred in 43 (24.1%) patients in the early postoperative period. Long-term macrohematuria was found in 23 (12.9%) patients, exacerbation of chronic pyelonephritis was in 13 (7.3%) patients after operation, acute urethritis developed in 7 (3.9%) patients, acute orchiepididymitis – in 9 (5, 0%) patients.
It has been proven that the total frequency of complications in patients with BPH who received levofloxacin in the early postoperative period was statistically significantly lower than in the patients who were prescribed ceftriaxone.
Conclusions. The use of levofloxacin for the prevention of early postoperative complications after TURP in patients with BPH complicated by acute urinary retention improves the results of surgical treatment by reducing the frequency of postoperative complications by 60%.
##plugins.themes.bootstrap3.article.details##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.
References
Gravas S, Cornu JN, Drake MJ, Gacci M, Gratzke C, Herrmann TRW, et al. Management of non-neurogenic male lower urinary tract symptoms (LUTS) [Internet]. Arnhem: EAU; 2022. 112 p. Available from: https://uroweb.org/guidelines/management-of-non-neurogenic-male-luts.
Vuichoud C, Loughlin KR. Benign prostatic hyperplasia: epidemiology, economics and evaluation. Can J Urol. 2015;22(1):1–6.
Pasechnikov SP, Gritsai VS, Glebov AS, Nasheda SV. Perebіg post-operational period fallow in the presence of the revealed bugs, which are transmitted by the path, in ailments to benign hyperplasia of the anterior slough. Man’s health. 2014;(2):75–8.
National Institute for Health and Care Excellence. Lower urinary tract symptoms in men: management. London: NICE; 2015. 24 p.
Pasechnikov SP, Dyachuk MD. Gradual analysis of the severity of laser vaporization with the device Dornier Medilas Urobeam 940 nm, transurethral resection of the anterior lesion and through the michural prostatectomy in patients with benign anterior lesion hyperplasia. Man’s health. 2015;(3):41–4.
Soler R, Andersson KE, Chancellor MB, Chapple CR, de Groat WC, Drake MJ, et al. Future direction in pharmacotherapy for non-neurogenic male lower urinary tract symptoms. Eur Urol. 2013;64(4):610–21. doi: 10.1016/j.eururo.2013.04.042.
Egan KB. The epidemiology of benign prostatic hyperplasia associated with lower urinary tract symptoms: prevalence and incident rates. Urol Clin North Am. 2016;43(3):289–97. doi: 10.1016/j.ucl.2016.04.001.
Gacci M, Corona G, Vignozzi L, Serni S, De Nunzio C, Tubaro A, et al. Metabolic syndrome and benign prostatic enlargement: a systematic review and meta-analysis. BJU Int. 2015;115(1):24–31. doi: 10.1111/bju.12728.
Nickel JC, Freedland SJ, Castro-Santamaria R, Moreira DM. Chronic prostate inflammation predicts symptom progression in patients with chronic prostatitis/chronic pelvic pain. J Urol. 2017;198(1):122–8. doi: 10.1016/j.juro.2017.01.035.
Sebastianelli A, Gacci M. Current status of the relationship between metabolic syndrome and lower urinary tract symptoms. Eur Urol Focus. 2018;4(1):25–7. doi: 10.1016/j.euf.2018.03.007.
Saidakova NO, Startseva LM, Kravchuk NG. The main indicators of urological assistance in Ukraine for 2019–2020 Kyiv; 2021. 203 p.
Lewis AL, Young GJ, Abrams P, Blair PS, Chapple C, Glazener CMA, et al. Clinical and patient-reported outcome measures in men referred for consideration of surgery to treat lower urinary tract symptoms: baseline results and diagnostic findings of the urodynamics for prostate surgery trial; randomised evaluation of assessment methods (UPSTREAM). Eur Urol Focus. 2019;5(3):340–50. doi: 10.1016/j.euf.2019.04.006.
Carvalho-Dias E, Miranda A, Martinho O, Mota P, Costa A, Nogueira-Silva C, et al. Serotonin regulates prostate growth through androgen receptor modulation. Sci Rep. 2017;7(1):15428. doi: 10.1038/s41598-017-15832-5.
Gritsay VS. Influx of infectivity of the anterior colitis by the workers of various taxonomic trips to the disease and the results of surgical treatment of ailments for benign hyperplasia of the anterior colitis [author’s abstract]. Kiev: Institute of Urology of the Academy of Medical Sciences of Ukraine; 2010. 20 p.
Bondarenko YM. Functional improvement of the lower slash paths and their correction in case of surgical treatment of ailments for benign hyperplasia of the anterior ridge [abstract]. Kiev: Institute of Urology of the Academy of Medical Sciences of Ukraine; 2007. 19 p.
Patrikeev AA. Medical rehabilitation of patients after transurethral resection of benign prostatic hyperplasia [abstract]. St. Petersburg; St. Petersburg Medical Academy of Postgraduate Education 2005. 20 p.
Mavrov GІ, Chіnov GP, Nagorniy OЄ. The peculiarities of sexuality and the structure of infections that are transmitted by state ways, especially older than 60 years. Klin imunol. Alergol. Infectol (special permit). 2011;(1):62–7.
Bohnen AM, Groeneveld FP, Bosch JL. Serum prostate-specific antigen as a predictor of prostate volume in the community: the Krimpen study. Eur Urol. 2007;51(6):1645–52. doi: 10.1016/j.eururo.2007.01.084.
Kirby RS. The natural history of benign prostatic hyperplasia: what have we learned in the last decade? Urol. 2000;56(5 Suppl 1):3–6. doi: 10.1016/s0090-4295(00)00747-0.
Vozianov OF, Pasechnikov SP, Gritsai VS. Splashing in the incidence of health problems of a different taxonomic approach to the vindication of early postoperative complications in ailments for benign hyperplasia of the anterior slough. Urol. 2010;(14):400 p.
Pasechnikov SP, Glebov AS. The role of health workers of the IPSSH in the development of an aggravation of surgical treatment of ailments for benign hyperplasia of the anterior slough. Medical aspects of men’s health. 2012;2(4):29–35.
Sernyak YuP, Krishtopa MV, Krizhanovsky ID. Paired evaluation of the results of prostatectomy and transurethral resection of the anterior lesion in patients with benign prostatic hyperplasia. Honey transport of Ukraine. 2012;(2):87–91.
Li F, Pascal LE, Zhou J, Zhou Y, Wang K, Parwani AV, et al. BCL-2 and BCL-XL expression are down-regulated in benign prostate hyperplasia nodules and not affected by finasteride and/or celecoxib. Am J Clin Exp Urol. 2018;6(1):1–10.
Sergienko NF, Kudryashov OI, Bratchikov OI. Begaev AI, Shchekochikhin AV, Shershnev SP, et al. Comparative characteristics of the results of modern surgical methods of treatment of patients with prostate adenoma. Urol. 2014;(1):73–8.
Martov AG, Maksimov VA, Yarovoy SYu. Transurethral galmium enucleation of prostate adenoma. Urol. 2011;(1):38–43.
Pryimak ІА, Martinyuk OV. Combination of levofloxacin with ornidazole for perioperative antibiotic prophylaxis in gynecological practice. Medical emergencies. 2012;(3):106–08.
