Erectile Dysfunction in Men Who Have Been Ill with COVID-19

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PDF (Українська)
Published: Dec 22, 2022
DOI: https://doi.org/10.30841/2307-5090.4.2022.274443
Keywords:
man, COVID-19, erectile dysfunction, cardiovascular diseases,

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Yevhen Luchytskiy
State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine», Ukraine
http://orcid.org/0000-0003-4894-5110
Vitaliy Luchytskiy
State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine», Ukraine
http://orcid.org/0000-0002-3515-3264
Halyna Zubkova
State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine», Ukraine
http://orcid.org/0000-0001-9555-1689
Viktoriya Rybal'chenko
State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine», Ukraine
http://orcid.org/0000-0001-9971-3526
Inna Skladanna
State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine», Ukraine
http://orcid.org/0000-0003-4456-8960

Abstract

The rapid spread of COVID-19 among the human population and the occurrence of complications of the disease, including sexual function, lead to the relevance of researches among the medical and scientific community.


The results of epidemiological studies indicate that COVID-19 more often affects men than women. Also, among the significant factors for the development of complications are the age and presence of comorbidities, among which diabetes, hypertension and obesity play an important role.


Erectile dysfunction (ED) in men today is considered as a marker of endothelial dysfunction and systemic inflammation caused by the background disease, and the presence of comorbidities.


Modern views on the pathogenesis of the development of ED in men who had COVID-19, and the features of development of sexual function in the presence of comorbidities are presented in the article.


According to modern positions, one of the main mechanisms of penetration of the SARS-CoV-2 virus is its interaction with angiotensin-converting enzyme 2 and transmembrane serine protease 2. Immunohistochemical studies have established a high expression of these enzymes in the endothelial cells of testicular tissue in men, which is currently considered by researchers as a direct damaging factor for the normal functioning of Leydig and Sertoli cells.


Subclinical hypogonadism, psychological distress and impaired pulmonary hemodynamics cause the potential development of ED. Also, in the pathogenesis of ED development in men who have been ill with COVID-19, important attention is paid to the role of systemic inflammation caused by the disbalance of proinflammatory and anti-inflammatory cytokines.


The relevant problem of today is the influence of coronavirus on the reproductive function of men. It is known that now male infertility has been diagnosed more often than before. In addition, there are enough reasonable factors to expect the effects of the negative effects of the COVID-19 not only on reproductive health but also on sexual and cardiovascular health of men, both in the short-term and in the long-term perspective.

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How to Cite
Luchytskiy, Y., Luchytskiy, V., Zubkova, H., Rybal’chenko, V., & Skladanna, I. (2022). Erectile Dysfunction in Men Who Have Been Ill with COVID-19. Health of Man, (4), 47–53. https://doi.org/10.30841/2307-5090.4.2022.274443
Issue
No. 4 (2022)
Section
Sexology and andrology
Copyright (c) 2022 Yevhen Luchytskiy, Vitaliy Luchytskiy, Halyna Zubkova, Viktoriya Rybal’chenko, Inna Skladanna

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.

Author Biographies

Yevhen Luchytskiy, State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine»

Yevhen V. Luchytskiy,

MD, PhD, DSc, Professor, Head of the Department of Reproductive Endocrinology

Vitaliy Luchytskiy, State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine»

Vitaliy Ye. Luchytskiy,

MD, PhD, DSc, Senior Researcher, Leading Researcher, Department of Reproductive Endocrinology

Halyna Zubkova, State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine»

Halyna A. Zubkova,

PhD in Biology, Senior Researcher, Head Researcher, Department of Reproductive Endocrinology

Viktoriya Rybal'chenko, State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine»

Viktoriya M. Rybal’chenko,

Senior Researcher, Department of Reproductive Endocrinology

Inna Skladanna, State Institution «V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine»

Inna I. Skladanna,

Junior Researcher, Department of Reproductive Endocrinology

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