Comparative Effectiveness of Antibiotic Prophylaxis of Postoperative Complications After Transurethral Resection of the Prostate

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Pavlo Samchuk
Hennadii Reznikov
Serhii Nasheda
Yaroslav Klymenko
Viktor Hrytsai

Abstract

Benign prostatic hyperplasia (BPH) is one of the most common benign diseases in men, as it leads to an enlarged prostate, the development of lower urinary tract symptoms, and worsens the quality of patient’s life. Surgical treatment is indicated to patients after non-effective drug treatment. Most often, transurethral resection of the prostate (TURP) is used.


The objective: to improve the results of TURP in patients with BPH and acute urinary retention by optimizing antibacterial prophylaxis of postoperative complications in the early postoperative period.


Materials and methods. An analysis of the surgical treatment of 179 patients with BPH with acute urinary retention after TURP was performed. The age of the patients varied from 51 to 84 years old, the average age was 64.9±5.1 years. All patients had a complex urological examination in the preoperative period. The patients were divided into two groups: I group – 85 patients after operation who were prescribed ceftriaxone in the early postoperative period; II group – 94 patients who received levofloxacin in the early postoperative period.


Results. It was determined that complications occurred in 43 (24.1%) patients in the early postoperative period. Long-term macrohematuria was found in 23 (12.9%) patients, exacerbation of chronic pyelonephritis was in 13 (7.3%) patients after operation, acute urethritis developed in 7 (3.9%) patients, acute orchiepididymitis – in 9 (5, 0%) patients.


It has been proven that the total frequency of complications in patients with BPH who received levofloxacin in the early postoperative period was statistically significantly lower than in the patients who were prescribed ceftriaxone.


Conclusions. The use of levofloxacin for the prevention of early postoperative complications after TURP in patients with BPH complicated by acute urinary retention improves the results of surgical treatment by reducing the frequency of postoperative complications by 60%.

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How to Cite
Samchuk, P., Reznikov, H., Nasheda, S., Klymenko, Y., & Hrytsai, V. (2022). Comparative Effectiveness of Antibiotic Prophylaxis of Postoperative Complications After Transurethral Resection of the Prostate. Health of Man, (4), 31–35. https://doi.org/10.30841/2307-5090.4.2022.274436
Section
For practicing physicians
Author Biographies

Pavlo Samchuk, Bogomolets National Medical University

Pavlo O. Samchuk,

MD, Assistant of Professor, Department of Urology

Hennadii Reznikov, Bogomolets National Medical University

Hennadii D. Reznikov,

MD, Assistant of Professor

Serhii Nasheda, International European University

Serhii V. Nasheda,

MD, PhD, Associate Professor, Department of Surgery

Yaroslav Klymenko, Bogomolets National Medical University

Yaroslav M. Klymenko,

MD, PhD, Аssociate Professor, Department of Urology

Viktor Hrytsai, Bogomolets National Medical University

Viktor S. Hrytsai,

MD, PhD, Associate Professor, Department of Urology

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