Clinical Features of Laboratory Diagnosis of Chronic Pelvic Pain Syndrome in Men
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Abstract
The article presents the results of a comparative analysis of primary and repeated laboratory examinations of patients with chronic prostatitis/chronic pelvic pain syndrome.
The objective: to evaluate the diagnostic value of cytokines secreting prostate, sperm and post massage urine.
Materials and methods. The study included 34 patients with CP/CPPS aged 18–45 years. Healthy volunteers (n=17) formed the control group. The prostatitis symptoms were assessed by NIH-CPSI scale, depressive symptoms – PHQ-9, and anxiety symptoms – GAD-7. All participants were subjected to microscopic and culture analysis of the expressed prostatic secretion, ejaculate and postmassage urine. Cytokines (TNF-α, IL-1, IL-8, IL-10) were determined using enzyme immunoassay.
Results. Even with a small number of observations there is no complete coincidence of the results of cultural and microscopic examination of the secretion of prostate, ejaculate and post-massage urine, which may be of clinical significance. Significant correlation between the symptoms of prostatitis, anxiety and depression with the leukocytes count as well as the concentration of cytokines in the ejaculate and prostate secretion was not found.
Conclusion. A single laboratory examination of a patient with prostatitis symptoms does not provide sufficient reproducibility of the results and, accordingly, casts doubt on the accuracy of the diagnosis. Developed therapeutic approaches may have an advantage if they take into account the possibility of diagnostic inaccuracies and have a therapeutic effect independently of them.##plugins.themes.bootstrap3.article.details##
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