Androgen Support and Erectile Function in Men with Diabetes Mellitus Type 2 and Obesity
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
The objective: to study to determine state of erectile function and androgen support in men with diabetes mellitus type 2 and obesity.
Materials and methods. A total of 56 men aged 35 to 65 years old were examined from CD2 (38 with obesity (group I) and 18 without obesity (group II)) and 82 healthy men who formed a control group. In blood, the concentration of follytropin (FSH), lutropin (LH), total testosterone (Ttot), testosterone free (Tfree), estradiol (E2), sex steroid binding globulin (SSBH) and prolactin (PRL) were determined by immunoferment method. The obesity criterion was considered as body mass index (BMI) >30 kg/m2. The state of erectile function was investigated using the International Index of Erectile Function Questionnaire (IIEF-15).
Results. The average blood serum levesl of Ttot and Tfree in both groups of patients were lower thsn in the control group. The average levels of estradiol in blood of , Group I patients were significantly higher compared to patients in Group ІІ. The average levels of pituitary hormones: FSH, LH and PRL in the patients of both examined groups were not significantly different from those in control group. The results of MIEF-15 inmen with type 2 diabetes and androgen deficiency revealed a marked decrease in all indicators of erectile function in the examined groups compared with the control ones. A more pronounced decrease in integrative indexes of MIEF-15 questionnair were in the subjects with obesity.
Conclusions. The obtained data (reduction of erectile function, orgasm, libido) indicate the presence of a violation of the hormonal component of the regulation of the sexual function in men with type 2 diabetes and obesity.##plugins.themes.bootstrap3.article.details##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.
References
Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity / D. Kapoor, H. Aldred, S. Clark [et al] // Diabetes Care. – 2007. – Vol. 30. – P. 911–917. https://doi.org/10.2337/dc06-1426
The association of body mass index with the risk of type 2 diabetes: a case control study nested in an electronic health records system in the United States / M. Ganz, N. Wintfeld, Q. Li [et al.] // Diabetol.& Metabolic Syndr. – 2014. – Vol. 6. – P. 50. https://doi.org/10.1186/1758-5996-6-50
Grossmann M. Testosterone and type 2 diabetes / M. Grossmann, E.J. Gianatti, J.D. Zajac // Curr. Opin. Endocrinol. Diabetes Obes. – 2010. – Vol. 17, N 3. – P. 247–256. https://doi.org/10.1097/MED.0b013e32833919cf
The relative contributions of aging, health and lifestyle factors to serum testosterone decline in men / T.G. Travison, A.B. Araujo, V. Kupelian [et al.] // J. Clin. Endocrinol.Metab. – 2007. – Vol. 92. – P. 549–555. https://doi.org/10.1210/jc.2006-1859
Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in Pomerania / R. Haring, T. Ittermann, H. Volzke [et al.] // Aging Male. – 2010. – Vol. 13. – P. 247–257. https://doi.org/10.3109/13685538.2010.487553
Ruige J.B. Does low testosterone affect adaptive properties of adipose tissue in obese men? / J.B. Ruige // Arch. Physiol. Biochem. – 2011. – Vol. 117, N 1. – P. 18–22. https://doi.org/10.3109/13813455.2010.525239
Larsen S.H. Sexual function and obesity (Lond) / S.H. Larsen, G. Wagner, B.L. Heitmann // Int J Obes (Lond). – 2007. – Vol. 1. – P. 1189–1198. https://doi.org/10.1038/sj.ijo.0803604
Decreased androgen levels in massively obese men may be associated with impaired function of gonadostat / N. Lima, H. Cavaliere, M. Knobel [et al.] // Int. J. Obes. Relat. Metab. Disord. – 2000. – Vol. 24(11). – P. 133–137. https://doi.org/10.1038/sj.ijo.0801406
Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism obese men / A. Vermeulen, J.M. Kaufman, J.R. Deslypere [et al.] // J. Clin. Endocrinol. Metab. – 1993. – Vol. 76. – P. 1140–1166. https://doi.org/10.1210/jcem.76.5.8496304
Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity / D. Kapoor, H. Aldred, S. Clark [et al] // Diabetes Care. – 2007. – Vol. 30. – P. 911–917. https://doi.org/10.2337/dc06-1426
Low testosterone levels are common and associated with insulin resistance in men with diabetes / M. Grossmann, M.C. Thomas, S. Panagiotopoulos [et al.] // J. Clin. Endocrin. Metab. – 2008. – Vol. 93. – P. 1834–1840. https://doi.org/10.1210/jc.2007-2177
Estradiol in elderly men / А. Vermeulen, J.M. Kaufman, S. Goemaere, I. van Pottelberg // Aging Male. – 2002. – Vol. 5. – P. 98–102. https://doi.org/10.1080/tam.5.2.98.102
Low estradiol Concentrations in men With Subnormal Testosterone Concentrations and Type 2 Diabetes / S. Dhindsa, R. Furlanetto, M. Vora [et al.] // Diabetes Care. – 2011. – Vol. 34. – P. 1854–1859. https://doi.org/10.2337/dc11-0208
EMAS Group. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study / A. Tajar, G. Forti, T.W. O‘Neil [et al.] // J. Clin. Endocrin. Metab. – 2010. – Vol. 95. – P. 1810–1818. https://doi.org/10.1210/jc.2009-1796
Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality / B. Baccetti, La Marca, P. Piomboni [et al.] // Hum. Reprod. –2002. – Vol. 17, N 10. – P. 2673–2677. https://doi.org/10.1093/humrep/17.10.2673
Testosterone and metabolic syndrome: a meta-analytic study / G. Corona, M. Monami, G. Ratsrelli [ et al.] // J. Sex. Med. – 2011. – Vol. 8. – P. 272–283. https://doi.org/10.1111/j.1743-6109.2010.01991.x
Huhtaniemi I. Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment / I. Huhtaniemi // Asia J.Androl. – 2014. – Vol. 16. – P. 192–202. https://doi.org/10.4103/1008-682X.122336
Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes / D. Kapoor, E. Goodwin, K.S. Channer, T.H. Jones // Eur J Endocrinol. – 2006. – Vol. 154. – P. 899–906. https://doi.org/10.1530/eje.1.02166
Channer K. Prospective evaluation of the effects of testosterone therapy in hypogonadal men with type 2 diabetes or metabolic syndrome: demographic analysis of TIMES2 study / K. Channer, C. Dumas // Diabetes. Vasc. Dis. Res. – 2007. – Vol. 4. – Р. 164. https://doi.org/10.3132%2Fdvdr.2007.012
Effect of 12 months of testosterone replacement therapy on metabolic syndrome components in hypogonadal men: data from the Testim Registry in the US (TRiUS) / R. Bhattacharya [et al.] // BMC Endoc. Disord. – 2011. – Vol. 11. – P. 18. https://doi.org/10.1186/1472-6823-11-18
Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip / J. Svatberg, I. Agledahl, T. Sildnes, Y. Figenschan // Int. J. Impot. Res. – 2008. – Vol. 20. – P. 378–387. https://doi.org/10.1038/ijir.2008.19
Testosterone as Potential Effective Therapy in Treatment of Obesity in Men with Testosterone Deficiency: A Review / F. Saad, A. Aversa, A.M. Isidori, L.J. Gooren // Curr Diabetes Rev. – 2012. – Vol. 8. – P. 131–143. https://dx.doi.org/10.2174%2F157339912799424573
Identification of late-onset hypogonadism in middle-aged and elderly men / F.C. Wu, A. Tajar, J.M. Beynon [et al.] // N. Engl. J. Med. – 2010. – Vol. 363. – Р. 123–135. https://doi.org/10.1056/NEJMoa0911101
Androgеns and diabеtic in mеn: Rеsults from thе Third National Hеalth and Nutrition Еxamination Syrvеy (NHANЕS III) / Е. Sеlvin, M. Fеinlеib, L. Zhang [еt al.] // Diabеtеs Carе. – 2007. – Vol. 30. – P. 234–238. https://doi.org/10.2337/dc06-1579
Zhody W. Androgen deficiency and abnormal penile duplex parameters in obese men with erectile dysfunction / W. Zhody, E.E. Kamal, Y.J. Ibrahim // Sex. Med. – 2007. – Vol. 4. – P. 797–808. https://doi.org/10.1111/j.1743-6109.2007.00499.x
