Estimation of the Effect of Tamsulosine on Posteyculator Pain
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
The objective: determination of the effect of tamsulosin on the reduction of symptoms associated with post-ejaculatory pain (PEB) in persons with chronic prostatitis and benign prostatic hyperplasia.
Materials and methods. On the basis of the State Institution “Institute of Urology of the National Academy of Medical Sciences of Ukraine”, outpatient supervision for year included 150 male patients from 31 to 57 years old, who were selected from a common cohort for the first time to see a urologist for people with symptoms of ESP. The patients were divided according to the principle of nosology: 47 with chronic abacterial prostatitis in unstable remission (group I), 51 with chronic bacterial prostatitis in unstable remission (group II) and 52 with BPH grade 1 (group III).
Results. In individuals of the І, ІІ and ІІІ groups, the disappearance/sharp decrease in the symptoms of PEB by 90 days was, respectively in 83,0%, 94,1% and 71,1% of patients from the primary data. Also, when interviewing patients, they indicated a decrease in the severity (strength) of post-ejaculatory pain, mainly during the first 30 days of treatment.
Conclusion. The use of tamsulosin is an effective strategy aimed at reducing the manifestations of post-ejaculatory pain, complicating the course of chronic prostatitis of any origin and benign prostatic hyperplasia.##plugins.themes.bootstrap3.article.details##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.
References
Pescatori E.S.; Pirozzi F. (2009) Eiaculazione dolorosa: una rassegna. Urologia. Vol. 76 Issue 4, Р. 230–235. https://doi.org/10.1177%2F039156030907600402
Mah K., Binik Y.M. (2001) The nature of human orgasm: a critical review of major trends // Clin Psychol Rev.; 21: 823–856. https://doi.org/10.1016/S0272-7358(00)00069-6
Helgason A.R., Fredrikson M., Adolfsson J., Steineck G. (1995) Decreased sexual capacity after external radiation therapy for prostate cancer impairs quality of life // Int J Radiat Oncol Biol Phys.; 32: 33–39. https://doi.org/10.1016/0360-3016(95)00542-7
Helgason A.R., Adolfsson J., Dickman P. et al. (1997) Factors associated with waning sexual function among elderly men and prostate cancer patients // J Urol.; 158: 155–159. https://doi.org/10.1097/00005392-199707000-00050
Rust J., Golombok S., Collier J. (1988) Marital problems and sexual dysfunction: how are they related? //Br J Psychiatry.; 152: 629–631. https://doi.org/10.1192/bjp.152.5.629
Hartman L.M. (1983) Effects of sex and marital therapy on sexual interaction and marital happiness. J Sex Marital Ther.; 9: 137–151. https://doi.org/10.1080/00926238308405841
Barnas J., Parker M., Guhring P., Mulhall J.P. (2005) The Utility of Tamsulosin in the Management of Orgasm-Associated Pain: A Pilot Analysis // EU. March. Vol.47, Issue 3, P. 361–365. https://doi.org/10.1016/j.eururo.2004.10.020
Lacroix P., Hubeaux K., Raibaut P., Amarenco G. (2007) Éjaculation douloureuse // Pelvi-périnéologie. December. Vol. 2, Issue 4, Р. 356–359. https://doi.org/10.1007/s11608-007-0166-5
Murphy A.B, Macejko A., Taylor A., Nadler R.B.(2009) Chronic prostatitis: management strategies. Drugs; 69(1):71–84. https://doi.org/10.2165/00003495-200969010-00005
Shoskes D.A. et al. (2004) Impact of post-ejaculatory pain in men with category III chronic prostatitis/chronic pelvic pain syndrom // J of Urol. Vol. 172, Issue 2, PP. 542–547. https://doi.org/10.1097/01.ju.0000132798.48067.23
Kaplan H. Post-ejaculatory pain syndrome (1993) // J. Sex & Marital Ther. Vol. 19. Issue 2, P. 91–103. https://doi.org/10.1080/00926239308404893
Perez, M.A., Skinner, E.C., Meyerowitz B.E. (2002) Sexuality and intimacy following radical prostatectomy: patient and partner perspectives. Health Psychol.; 21: 288–293. https://psycnet.apa.org/doi/10.1037/0278-6133.21.3.288
Barnas J.L., Pierpaoli S., Ladd P., et al. (2004) The prevalence and nature of orgasmic dysfunction following radical prostatectomy. BJU Int.; Sep;94(4):603–5. https://doi.org/10.1111/j.1464-410X.2004.05009.x
Steg A., Zerbib M., Conquy S. (1988) Sexual disorders after an operation for benign prostatic hypertrophy. Ann Urol (Paris).; 22: 129–133.
Pryor J.P., Hendry W.F. (1991) Ejaculatory duct obstruction in subfertile males: analysis of 87 patients. Fertil Steril.; 56: 725–30. https://doi.org/10.1016/s0015-0282(16)54606-8
Goldwasser B.Z., Weinerth J.L., Carson C.C. (1985) Ejaculatory duct obstruction: the case for aggressive diagnosis and treatment. J Urol.; 134: 964–6. https://doi.org/10.1016/S0022-5347(17)47550-1
Fisch H., Kang Y.M., Johnson C.W., Goluboff E.T. (2002) Ejaculatory duct obstruction. Curr Opin Urol.; 12: 509–15. https://doi.org/10.1097/01.mou.0000039452.39928.92
Turek P.J., Magana J.O., Lipshultz L.I. (1996) Semen parameters before and after transurethral surgery for ejaculatory duct obstruction. J Urol.; 155: Р. 1291–1293. https://doi.org/10.1016/S0022-5347(01)66246-3
Paick J.S., Kim S.H., Kim S.W. (2000) Ejaculatory duct obstruction in infertile men. BJU Int.; 85: Р. 720–724. https://doi.org/10.1046/j.1464-410x.2000.00600.x
Johnson C.W., Bingham J.B., Goluboff T.T., Fisch H. (2005) Transurethral resection of the ejaculatory ducts for treating ejaculatory symptoms // BJU Int. Vol. 95, Issue 1, Jan., P. 117–119. https://doi.org/10.1111/j.1464-410X.2004.05261.x
Newman H.F., Reiss H., Northup J.D. (1982) Physical basis of emission, ejaculation, and orgasm in the male. Urology.; 19: Р. 341–350. https://doi.org/10.1016/0090-4295(82)90186-8
NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence (1993). JAMA. 1993; 270: 83–90. https://doi.org/10.1001/jama.1993.03510010089036
Helgason, A., Adolfsson, J., Dickman, P., Fredrikson, M., Steineck, G. (1998) Distress due to unwanted side-effects of prostate cancer treatment is related to impaired well-being (quality of life). Prostate Cancer Prostatic Dis.; 1: 128–133. https://doi.org/10.1038/sj.pcan.4500226
Koeman, M., van Driel, M.F., Schultz, W.C., Mensink, H.J. (1996) Orgasm after radical prostatectomy. Br J Urol.; 77: 861–864. https://doi.org/10.1046/j.1464-410x.1996.01416.x
Goriunov V.G., Davidov M.I. (1997) Sexual readaptation after the surgical treatment of benign prostatic hyperplasia. Urol Nefrol (Mosk). 1997; 20–24.
Nickel J.C., Narayan P., McKay J., Doyle C. (2004) Treatment of chronic prostatitis/chronic pelvic pain syndrome with tamsulosin: a randomized double blind trial. J Urol.; 171: 1594–1597. https://doi.org/10.1097/01.ju.0000117811.40279.19
Narayan P., Evans C.P., Moon T. (2003) Long-term safety and efficacy of tamsulosin for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. J Urol.; 170: 498–502. https://doi.org/10.1097/01.ju.0000076140.68657.fd
Abrams P., Schulman C.C., Vaage S. (1995) Tamsulosin, a selective alpha 1c-adrenoceptor antagonist: a randomized, controlled trial in patients with benign prostatic ’obstruction’ (symptomatic BPH). The European Tamsulosin Study Group. Br J Urol.; 76: 325–336. https://doi.org/10.1111/j.1464-410x.1995.tb07709.x
Demyttenaere K., Huygens R. (2002) Painful ejaculation and urinary hesitancy in association with antidepressant therapy: relief with tamsulosin. Eur Neuropsychopharmacol. 2002; 12: 337–341. https://doi.org/10.1016/S0924-977X(02)00040-8
Cytron S., Simon D., Segenreich E. et al. (1987) Changes in the sexual behavior of couples after prostatectomy. A prospective study. Eur Urol.; 13: 35–38. http://dx.doi.org/10.1159/000472733
Merrick G.S., Wallner K., Butler W.M., Lief J.H., Sutlief S. (2001) Short-term sexual function after prostate brachytherapy. Int J Cancer.; 96: 313–319. https://doi.org/10.1002/ijc.1028
Hofner K. (1999) Alpha(1)-blocker therapy in the nineties: focus on the disease. Prostate Cancer Prostatic Dis.; 2: S9–S15. https://doi.org/10.1038/sj.pcan.4500368
Sakakibara R., Shinotoh H., Uchiyama В. et al. (2001) Questionnaire-based assessment of pelvic organ dysfunction in Parkinson’s disease. Auton Neurosci.; 92: 76–85. https://doi.org/10.1016/S1566-0702(01)00295-8
Das Gupta R., Fowler C.J.(2002) Sexual and urological dysfunction in multiple sclerosis: better understanding and improved therapies. Curr Opin Neurol.; 15: 271–278. http://dx.doi.org/10.1097/00019052-200206000-00008
Fedoroff J.P., Peyser C., Franz M.L., Folstein S.E. (1994) Sexual disorders in Huntington’s disease // J Neuropsychiatry Clin Neurosci.; 6: 147–153. https://doi.org/10.1176/jnp.6.2.147
Bergman B., Nilsson S., Petersen I. (1979) The effect on erection and orgasm of cystectomy, prostatectomy and vesiculectomy for cancer of the bladder: a clinical and electromyographic study// Br J Urol.; 51:114–120. https://doi.org/10.1111/j.1464-410x.1979.tb02843.x
Горпинченко І.І., Гурженко Ю.М., Спиридоненко В.В. (2017) Корекція біохімічних показників еякуляту при застосуванні Вітапрост Форте у чоловіків з хронічними запальними захворюваннями простатовезикулярного комплексу, ускладнених екскреторно-токсичною безплідністю // Здоровье мужчины. – № 3 (62). – С. 40–44. https://doi.org/10.30841/2307-5090.3(62).2017.117760
Rikiya Taoka, Yoshiyuki Kakehi (2017) The influence of asymptomatic inflammatory prostatitis on the onset and progression of lower urinary tract symptoms in men with histologic benign prostatic hyperplasia //Asian Journal of Urology.; 4; 3; Р. 158–163. https://doi.org/10.1016/j.ajur.2017.02.004
Stanley E., Althof C., McMahon G. (2016) Contemporary Management of Disorders of Male Orgasm and Ejaculation, Urology; 93; 9–21. https://doi.org/10.1016/j.urology.2016.02.018
Kirby М. (2016) Male Sexual Dysfunction: A Clinical Guide. Treatment of premature ejaculation and ejaculatory disorders. P. 143–151. https://doi.org/10.1002/9781118746509.ch17
O’Leary M. (2005) Orgasmic Pain and a Detectable PSA Level after Radical Prostatectomy // Rev Urol; 7(4); 240–241. Full text
Ilie C.P., Mischianu D.L., Pemberton R.J. (2007) Painful ejaculation. BJU Int.; Jun;99(6):1335–1339. https://doi.org/10.1111/j.1464-410X.2007.06664.x
Francisca E.A., d’Ancona F.C., Meuleman E.J., Debruyne F.M., de la Rosette J.J. (1999) Sexual function following high energy microwave thermotherapy: results of a randomized controlled study comparing transurethral microwave thermotherapy to transurethral prostatic resection. J Urol.;161: 486–490. https://doi.org/10.1016/s0022-5347(01)61930-x
Shih-Tsung Huang (2016) Impacts of medical treatments for lower urinary tract symptoms suggestive to benign prostatic hyperplasia on male sexual functions, Urological Science, 27; 1; 3–7. https://doi.org/10.1016/j.urols.2015.12.001
Marita P., McCabe В., Ira D. etal. (2015) Incidence and Prevalence of Sexual Dysfunction in Women and Men: A Consensus Statement from the Fourth International Consultation on Sexual Medicine. The Journal of Sexual Medicine, 2016, 13, 2, 144–152. https://doi.org/10.1016/j.jsxm.2015.12.034
Nickel J.C., Elhilali M., Vallancien G. (2005) ALF-ONE Study. Benign prostatic hyperplasia (BPH) and prostatitis: prevalence of painful ejaculation in men with clinical BPH // BJUI. Vol. 95, Issue 4. P. 571–574. https://doi.org/10.1111/j.1464-410X.2005.05341.x
Marszalek M. (2007) Symptoms Suggestive of Chronic Pelvic Pain Syndrome in an Urban Population: Prevalence and Associations With Lower Urinary Tract Symptoms and Erectile Function // J. Urol. 177; 5; 1815–1819. https://doi.org/10.1016/j.juro.2007.01.008
Lee S.V.H. et al. (2008) Adverse Impact of Sexual Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Urology.71; 1; 79–84. https://doi.org/10.1016/j.urology.2007.08.043
Bancroft J., Loftus J., Long J.S. (2003) Distress about sex: a national survey of women in heterosexual relationships. Arch Sex Behav.; 32: 193–208. https://doi.org/10.1023/A%3A1023420431760
Safarinejad M.R. (2006) Safety and efficacy of tamsulosin in the treatment of painful ejaculation: a randomized, double-blind, placebo-controlled study. Int.J. of Impotence Research.; 18, 527–533. https://doi.org/10.1038/sj.ijir.3901466
Delavierrea D., Sibertbc J., Rigaudde L., Labatd J.J. (2014) L’éjaculation douloureuse. Painful ejaculation. 24; 7; 414–420. https://doi.org/10.1016/j.purol.2013.11.008
Reet Mändar (2013) Microbiota of male genital tract: Impact on the health of man and his partner. Pharmacological Research.; 69; 1; 32–41. https://doi.org/10.1016/j.phrs.2012.10.019
Tran C.N., Shoskes D.A. (2013) Sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome. World J Urology. 31, 4, 741–6. https://doi.org/10.1007/s00345-013-1076-5
Nickel J.C. Campbell-Walsh Urology, 2012, 327 p.
Горпинченко И.И., Спиридоненко В.В. Решение проблемы преждевременной эякуляции в практике уролога (2017). Здоровье мужчины. № 3 (62). – С. 9–13. https://doi.org/10.30841/2307-5090.3(62).2017.117657
