Ways of Improvement of Diagnostic and Treatment of Patients with Acute Epididymitis
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Abstract
The objective: to study the state of the prooxidant system and the system of antioxidant protection in patients with acute epididymitis and the content of essential elements as Zn and Cu in these patients.
Маterials and methods. To determine the activity of antioxidant enzymes and essential microelementes, 120 patients with acute epididymitis were surveyed in the Urological Clinic of National Military–Medical Clinical Centre «GVKG». The patients were divided into 4 Groups: Group І (n=40) – patients, suffering from acute epididymitis, were treated according to the guidelines, Group ІІ (n=40) – patients, suffering from acute epididymitis, whose treatment included an antibiotic ofloxacin, Group ІІІ (n=40) – patients, suffering from acute epididymitis, whose complex of the treatment included an antibiotic ofloxacin, l-arginine and suppositories, which contains a fibrinolytic – streptokinase (15,000 IU) and proteolytic – streptodornase (1 250 IU), Group control – n=20 conditionally healthy patients.
Results. It was found that there is a significant dependence between the content of Zn, Cu in blood and enzymes of the system of antioxidant protection.
Conclusion. Metabolic changes in the presence of a decrease of Zn and excess Cu correlate with an imbalance in the system of antioxidant protection, namely the decrease in the level of antioxidant defense enzymes and excess the level of products of oxidative modification of proteins.##plugins.themes.bootstrap3.article.details##
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