Pathogenic aspects of the development of type ІІ diabetes: the role of glucocorticoid metabolism

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Published: Oct 29, 2015
DOI: https://doi.org/10.30841/2307-5090.3(54).2015.105132
Keywords:
type 2 diabetes, the activity of 11β-hydroxysteroiddehydrogenase type 1 tetrahydroderivatives of cortisol, tetrahydroderivatives cortisone, insulin, testosterone-estradiol binding globulin, obesity,

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О. В. Корпачева-Зінич
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України», м. Київ, Ukraine

Abstract

It is believed that the development of type 2 diabetes contributes to an imbalance of glucocorticoids and their metabolites, and reaffirmed the importance of the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-GSD1) in the regulation of metabolic processes by maintaining the optimal level of cortisol in tissues. In the present study we investigated features of changes in the general activity of 11β-HSD in male with type 2 diabetes, by determining the ratio of cortisol and cortisone metabolites that are secreted in the urine, depending on the level of hyperinsulinemia, glucose, and anthropometric indicators. Increase of activity of 11β-HSD 1, as well as urinary metabolites of cortisol and the total amount of corticosteroids is set at low concentrations SHBG compared with those in the control group. For patients with insufficiency of insulin the increase of egestion of tetrahydroderivatives of cortisol and cortisone is fixed in comparison with those values which were determined by high insulin. The highest activity of 11β-GSD1 observed with android type of obesity. These data confirm the dependence of insulinemia glucocorticoid metabolism and fat distribution. Considering the findings, early diagnosis and the development of therapies that are adjusted to imbalance of glucocorticoids is appropriateness to prevent the development of insulin resistance, obesity and diabetes.

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How to Cite
Корпачева-Зінич, О. В. (2015). Pathogenic aspects of the development of type ІІ diabetes: the role of glucocorticoid metabolism. Health of Man, (3(54), 38–40. https://doi.org/10.30841/2307-5090.3(54).2015.105132
Issue
No. 3(54) (2015)
Section
For practicing physicians
Copyright (c) 2020 О. В. Корпачева-Зінич

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Author Biography

О. В. Корпачева-Зінич, ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України», м. Київ

O.V. Korpacheva-Zinych

References

beta-hydroxysteroid dehydrogenase type 1 in adipose tissue and prospective changes in body weight and insulin resistance / J. Koska, B. de Courten, D.J. Wake [et al.] // Obesity. – 2006. – Vol. 14, N 9. – P. 1515–1522.

Acute In Vivo Regulation of 11(beta)Hydroxysteroid Dehydrogenase Type 1 Activity by Insulin and Intralipid Infusions in Humans / D.J. Wake, N.Z.M. Homer, R. Andrew [et al.] // J. Clin. Endocrinol. Metab. – 2006. – Vol. 91, N 11. – P. 4682–4688.

Anagnostis P. The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis / P. Anagnostis // J. Clin. Endocrinol. Metab. – 2009. – 94.– N 8. – P. 2692–701.

Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middlelaged men / H.B. Holt, S.H. Wild, A.D. Postle [et al.] // Diabetologia. – 2007. – Vol. 50, N 5. – P. 1024–1032.

Gagliardi L. Screening for subclinical Cushing’s syndrome in type 2 diabetes mellitus: low false-positive rates with nocturnal salivary cortisol / L. Gagliardi, I.M. Chapman, P. O’Loughlin // Horm. Metab. Res. – 2010. – Vol. 42, N 4. – P. 280–284.

Ge R. Corticosteroid-mediated programming and the pathogenesis of obesity and diabetes / R. Ge, Y. Huang, G. Liang // J. Steroid. Biochem. Mol. Biol. – 2010. – Vol. 122, N 1–3. – P. 3–9.

Kerstens M.N. Tissue-specific changes in cortisol metabolism and their potential role in the metabolic syndrome / M.N. Kerstens, B.H. Wolffenbuttel, R.P. Dullaart // Ned. Tijdschr. Geneeskd. – 2005. – Vol. 149, N 16. – P. 871–876.

Morgan S.A. 11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes / S.A. Morgan, J.W. Tomlinson // Expert. Opin. Investig. Drugs. – 2010. – Vol. 19, N 9. – P. 1067–1076.

Morton N.M. Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease / N.M. Morton // Mol. Cell. Endocrinol. – 2010. – Vol. 316, N 2. – P. 154–164.

Relationships between cortisol level, mortality and chronic diseases in older persons / RM. Schoorlemmer, GM. Peeters, NM. van Schoor [et al.] // Clin. Endocrinol. (Oxf). – 2009. – Vol. 71, N 6. – P. 779–786.

Stewart P.M. 11β-hydroxysteroid dehydrogenase / P.M. Stewart, Z.S. Krozowski // Vitam. Horm. – 1999. – 57. – P. 249–324.

Stewart P.M. Tissue-specific Cushing’s syndrome,11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action / P.M. Stewart // Eur. J.Endocrinol. – 2003. – Vol. 149, N 3. – P. 163–168.

Stimson R.H. Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans / R.H. Stimson // Diabetes. – 2009. – Vol. 58, N 1. – P. 46–53.

Tissue-specific dysregulation of cortisol metabolism in human obesity / E. Kask, T. Olsson, S. Soderberg [et al.] // J. Clin. Endocrinol. Metab. – 2001. – Vol. 86, N 3. – P. 1418–1421.

Walker B.R. Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning / B.R. Walker // Proc. Nutr. Soc. – 2007. – Vol. 66, N 1. – P. 1–8.

Weight loss increases 11β-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue / W. Tomlinson, S. Moore, P.M.S. Clarck [et al.] // J. Clin. Endocrinol.Metab. – 2004. – Vol. 89, N 6. – P. 2711–2716.

Безверхая Т.П. Функциональная активность коры надпочечников и обмен кортизола у больных сахарным диабетом: Автореф. дис. ... док. мед.наук. / Безверхая Т.П.; Киев, 1978. – 45 с.