Problems of іdіopathic male infertility
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
The article presents the analysis of the effectiveness of treatments for idiopathic male infertility.
The objective: to evaluate the association of indicators of semen, cytokines TNF-α and TGF-β1, as well as antioxidant properties of ejaculate in male idiopathic infertility, as well as the dynamics of the state of fertility under the influence of antioxidant agents.
Patients and methods. 32 patients were included in the study with idiopathic infertility in the age range 18–45 years. The dynamics of sperm parameters (including its antioxidant properties – NST-test) and ejaculate cytokines (TNF-alpha, TGF-beta1) under the influence of Novofertil receiving for 6 months (1 caps. 2 times / day) was studied.
Results. There was a statistically significant (p<0.05) increase in sperm motility and the number of live sperm, there was a statistically significant association between indicators of NST test, and sperm motility, NST test and the number of live sperm. Immunological rejection dynamics have not been.
Conclusion. Antioxidant agent confirmed efficacy in idiopathic male infertility.
##plugins.themes.bootstrap3.article.details##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.
References
de Kretser D.M. Male infertility // Lancet. – 1997. – № 349. – P. 787–790.
Wang C., Swerdloff R.S. Limitations of semen analysis as a test of male fertility and anticipated needs from newer tests // Fertility and Sterility. – 2014. – № 102. – P. 1502–1507.
Leifke E., Nieschlag E. Male infertility treatment in the light of evidence-based medicine // Andrologia. – 1996. – № 28 (Suppl 1). – P. 23–30.
Jung J.H., Seo J.T. Empirical medical therapy in idiopathic male infertility: promise or panacea? // Clinical and Experimental Reproductive Medicine. – 2014. – № 41. – P. 108–114
Rittenberg V., El-Toukhy T. Medical treatment of male infertility // Human Fertility. – 2010. – № 13. – P. 208–216.
Aston K.I. Genetic susceptibility to male infertility: news from genome-wide association studies // Andrology. – 2014. – № 2 (3). – P. 315–321.
de Lamirande E., Harakat A., Gagnon C., Human sperm capacitation induced by biological fluids and progesterone, but not by NADH or NADPH, is associated with the production of superoxide anion //Andrology. – 1998. – № 19 (2). – P. 215–225.
Wang X., Sharma R.K., Sikka S.C. et al. Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility // Fertil. Steril. – 2003. – № 80 (3). – P. 531–535.
Mazzilli F., Rossi T., Marchesini M., Ronconi C., Dondero F. Superoxide anion in human semen related to seminal parameters and clinical aspects // Fertil. Steril. – 1994. – № 62 (4). – P. 862–868.
Sharma R.K., Pasqualotto F.F., Nelson D.R., Thomas A.J.Jr., Agarwal A. The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility // Hum. Reprod. – 1999. – № 14 (11). – P. 2801–2807.
Zalata A., Hafez T., Mahmoud A., Comhaire F. Relationship between resazurin reduction test, reactive oxygen species generation, and gamma-glutamyltransferase // Hum. Reprod. – 1995. – № 10 (5). – P. 1136–1140.
Pahune P.P., Choudhari A.R., Muley P.A. The total antioxidant power of semen and its correlation with the fertility potential of human male subjects // Journal of Clinical and Diagnostic Research. – 2013. – № 6 (7). – P. 991–995.
Greco E., Iacobelli M., Rienzi L., Ubaldi F., Ferrero S., Tesarik J. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment // Journal of Andrology. – 2005. – № 3 (26). – P. 349–353.
Safarinejad M.R. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study // International Urology and Nephrology. – 2012. – № 3 (44). – P. 689–700.
Gupta N.P., Kumar R. Lycopene therapy in idiopathic male infertility – a preliminary report // International Urology and Nephrology. – 2002. – № 3 (34). – P. 369–372.
Chen X.F., Li Z., Ping P., Dai J.C., Zhang F.B., Shang X.J. Efficacy of natural vitamin E on oligospermia and asthenospermia: a prospectivemulti-centered randomized controlled study of 106 cases // Zhonghua Nan Ke Xue. – 2012. – № 5 (18). – P. 428–431.
Wang Y.X., Yang S.W., Qu C.B. et al. L-carnitine: safe and effective for asthenozoospermia // Zhonghua Nan Ke Xue. – 2010. – № 5 (16). – P. 420–422.
Moslemi M.K., Tavanbakhsh S. Seleniumvitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate // International Journal of General Medicine. – 2011. – № 4. – P. 99–104.
Cavallini G., Magli M.C., Crippa A., Ferraretti A.P., Gianaroli L. Reduction in sperm aneuploidy levels in severe oligoasthenoteratospermic patients after medical therapy: a preliminary report. // Asian Journal of Andrology. – 2012. – № 4 (14). – P. 591–598.
Greco E., Romano S., Iacobelli M. et al. ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment // Human Reproduction. – 2005. – № 9 (20). – P. 2590–2594.
Safarinejad M.R. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men // Journal of Urology. – 2009. – № 1 (182), pp. 237–248.
Safarinejad M.R., Safarinejad S., Shafiei N., Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a doubleblind, placebo controlled, randomized study // Journal of Urology. – 2012. – № 2 (188). – P. 526–531.
Piomboni P., Gambera L., Serafini F., Campanella G., Morgante G., de Leo V. Sperm quality improvement after natural anti-oxidant treatment of asthenoteratospermic men with leukocytospermia // Asian Journal of Andrology. – 2008. – № 2 (10). – P. 201–206.
Balercia G., Mosca F., Mantero F. et al. Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study // Fertility and Sterility. – 2004. – № 1 (81). – P. 93–98.
Akmal M., Qadri J.Q., Al-Waili N.S., Thangal S., Haq A., Saloom K.Y. Improvement in human semen quality after oral supplementation of vitamin C // Journal of Medicinal Food. – 2006. – № 3 (9). – P. 440–442.
Santi D., Granata A.R.M., Simoni M. FSH treatment of male idiopathic infertility improves pregnancy rate: a meta-analysis // Endocrine Connections. – 2015. – № 4. – P. 46–58.
Blumenfeld Z., Frisch L., Conn P.M. Gonadotropin-releasing hormone (GnRH) antibodies formation in hypogonadotropic azoospermic men treated with pulsatile GnRHdiagnosis and possible alternative treatment // Fertil. Steril. – 1988. – № 50. – P. 622–629.
Gordetsky J., van Wijngaarden E., O’Brien J. Redefining abnormal follicle-stimulating hormone in the male infertility population // BJU Int. – 2012. – № 110. – P. 568–752.
Clark R.V., Sherins R.J. Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone. Results of a double-blinded, randomized, placebo-controlled trial with crossover // J. Androl. – 1989. – № 10. – 240–247.
Pavlovich C.P., King P., Goldstein M. et al. Evidence of a treatable endocrinopathy in infertile men // J. Urol. – 2001. – № 165. – P. 837–841.
Chua M.E., Escusa K.G., Luna S. et al. Revisiting oestrogen antagonists (clomiphene or tamoxifen) as medical empiric therapy for idiopathic male infertility: a meta-analysis // Andrology. – 2013. №1. – P.749-757.
Vandekerckhove P., Lilford R., Vail A. et al. Clomiphene or tamoxifen for idiopathic oligo/asthenospermia // Cochrane Database Syst. Rev. 2000 (2):CD000151.
Willets A.E., Corbo J.M., Brown J.N. Clomiphene for the treatment of male infertility // Reprod. Sci. – 2013. – № 20. – P. 739–744.
Drannik G.M., Gorpinchenko I.I., Poroshina T.V., Nurimanov K.R., Savchenko V.S., Dobrovol'ska L.I. Tarasova I.I. Efekti citokiniv ejakuljatu na pokazniki patospermii' u hvorih na hronichnij abakterial'nij prostatit, uskladnenij ekskretorno-toksichnim nepliddjam // Zdorov'e muzhchiny. – 2013. – № 3 (43). – S. 181–184.
Nurimanov K.R. Vpliv lejkocitiv ta ginterferonu spermi na pokazniki fertil'nosti u hvorih na hronichnij abakterial'nij prostatit // Zdorov'e muzhchiny. – 2015. – № 4 (55). – S. 82–84.
Havrylyuk A., Chopyak V., Boyko Y, Kril I., Kurpisz M. Cytokines in the blood and semen of infertile patients // Cent. Eur. J. Immunol. – 2015. – № 40 (3). – P. 337–44.
Gorpinchenko I.I. Metabolicheskaja terapija v kompleksnom lechenii jekskretornotoksicheskogo besplodija. Opyt primenenija preparata gammafertil // Zdorov'e muzhchiny. – 2015. – № 3 (54). – S. 36–41.
World Health Organization, WHO Laboratory Manual for the Examination and Processing of Human Semen, WHO Press, Geneva, Switzerland, 5th edition, 2010.
