Clinical significance of determining neovascularization in patients with germ cell tumor of testis

##plugins.themes.bootstrap3.article.sidebar##

PDF (Українська)
Published: Dec 21, 2015
DOI: https://doi.org/10.30841/2307-5090.4(55).2015.104842
Keywords:
angiogenesis, neovasculatization, germ cell tumor, endothelial growth factor (VEGF),

##plugins.themes.bootstrap3.article.main##

А. М. Романенко
ГУ «Институт урологии НАМН Украины», Ukraine
Л. М. Захарцева
Киевский городской клинический онкологический центр, Ukraine
А. В. Сакало
ГУ «Институт урологии НАМН Украины», Ukraine

Abstract

Study of the angiogenesis during the growth of malignant tumor is a critical issue of modern oncology. These studies yielded drugs and combinations of medicines of anti VEGF therapy. One of main regulators of angiogenesis is vessel endothelial growth factor (VEGF). We performed quantitative analysis of  neoangiogenesis by examining vascular density (VD) in 51 patients with primary tumor of testis, and compared with clinical and morphological features of patients. We established probable correlation between VD level and stage, progression and prognosis of the disease (р=0.001, р=0.013 and р=0.003, respectively) and intensity of   expression of VEGF (р<0.0001). Neovasculatisation of nonsemi   nomatous tumors is higher than that of seminomatous ones  (р=0.019).

##plugins.themes.bootstrap3.article.details##

How to Cite
Романенко, А. М., Захарцева, Л. М., & Сакало, А. В. (2015). Clinical significance of determining neovascularization in patients with germ cell tumor of testis. Health of Man, (4(55), 134–137. https://doi.org/10.30841/2307-5090.4(55).2015.104842
Issue
No. 4(55) (2015)
Section
Oncology
Copyright (c) 2020 А. М. Романенко, Л. М. Захарцева, А. В. Сакало

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.

Author Biographies

А. М. Романенко, ГУ «Институт урологии НАМН Украины»

А.М. Romanenko

Л. М. Захарцева, Киевский городской клинический онкологический центр

L.M. Zakhartseva

А. В. Сакало, ГУ «Институт урологии НАМН Украины»

А.V. Sаkаlо

References

Sa Nguanraksa D. High vascular endothelial growth factor gene expression predicts poor outcome in patients with non luminal A breast cancer / D. Sa Nguanraksa, T. Chuangsuwanich [et al.] // Mol Clin Oncol. – 2015. 3 (5). – P. 1103–1108.

Linardou H. The prognostic and predictive value of mRNA expression of vascular endothelial growth factor family members in breast cancer: a study in primary tumors of high risk early breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial / H. Linardou, KT. Kalogeras, R. Kronenwett [et al.] // Breast Cancer Res. – 2012. Nov 12.

Linardou H, Prognostic Significance of VEGFC and VEGFR1 mRNA

Expression According to HER2 Status in Breast Cancer: A Study of Primary Tumors from Patients with High risk Early Breast Cancer Participating in a Randomized Hellenic Cooperative Oncology Group Trial / H. Linardou, KT. Kalogeras, R. Kronenwett [et al.] // Anticancer Res. – 2015. – 35 (7). – P. 4023–36.

Sandra F. Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti angiogenic therapies / F. Sandra, M. Rui, M. Antonio [et al.] // World J Clin Oncol. – 2011. – 2 (6). – P. 272–280.

Keiji I. The Prognostic Value of Angiogenesis Factor Expression for Predicting Recurrence and Metastasis of Bladder Cancer after Neoadjuvant Chemotherapy and Radical Cystectomy / I. Keiji, W. Joel, K. Takashi [et al.] // Clin Cancer Res December – 2000. – 6. – P. 4866–4873.

Silván U. Vascularization of testicular germ cell tumours: evidence from experimental teratocarcinomas / U. Silván, A. Díez Torre, L. Jiménez Rojo [et al.] // Int J of Andrology. – 2010. – 33. – P. 765–774.

Fukuda S. Expression of vascular endothelial growth factor in patients with testicular germ cell tumors as an indicator of metastatic disease / S. Fukuda, T. Shirahama, Y. Imazono [et al.] // Cancer. – 1999. – 85. – P. 1323–1330.

Viglietto G. Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta derived growth factor / G. Viglietto, A. Romano, D. Maglione [et al.] // Oncogene. – 1996. – 13 (3). – P. 577–87.

Silván U. Vasculogenesis and angiogenesis in nonseminomatous testicular germ cell tumors / U. Silván, A. Díez Torre, Z. Bonilla [et al.] // Urologic Oncology. – 2015. – 33. – P. 268.

Olivarez D. Neovascularization in Clinical Stage A Testicular Germ Cell Tumor: Prediction of Metastatic Disease / D. Olivarez, T. Ulbright, W. DeRiese [et al.] // Cancer Research. – 1994. – 54. – P. 2800–2802.

Subbiah V. Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive a to Sunitinib (Sutent®) VEGFR2/PDGFRβ/c kit/FLT3/RET/CSF1R inhibitor in a phase II trial / V. Subbiah, Meric Bernstam F., G. Mills [et al.] // J Hematol Oncol. – 2014. – 7. – P. 52.

Bergers G. Modes of resistance to anti-angiogenic therapy / G. Bergers, D. Hanahan // Nat Rev Cancer. – 2008. – 8 (8). – P. 592–603.

Oscar A. Serum human chorionic gonadotropin is associated with angiogenesis in germ cell testicular tumors // A. Oscar, M. Rosa, O. Michel [et al.] // J Exp Clin Cancer Res. – 2009. – 28 (1). – P. 120.

Romanenko A.M. Microvessel density is high in clear cell renal cell carcino mas of Ukrainian patients, exposed to chronic persistent low dose ionizing radiation after the Chernobyl accident / A.M. Romanenko, A. Ruis Sauri, L. Morell Quadreny [et al.] // Virchows Arch. – 2012. – 460. – P. 611–619.