Hypoactive Sexual Desire Due to Endocrine Pathology, Diseases of Internal Organs, Tumors, Other Diseases and Conditions, Ionizing Radiation, Smoking, Alcohol, and Drugs


Garnik Kocharyan


Data on hypoactive sexual desire, which occurs in patients with hypogonadism, its classification, anatomical features, and the author’s clinical example of castration-induced hypogonadism are presented. It is reported that if castration is carried out before puberty, then sexual desire does not develop, and if after its completion, only a decrease in its intensity is noted. This is due to the fact that hormonal changes that occur during puberty increase the “sensitivity” of the brain, and therefore the “mental component” of sexual desire develops, which does not disappear after castration.

It is noted that the dependence of libido and sexual activity of men on androgens is much less than in animals. Moreover, it is reported that this dependence is much less in people with a higher level of intellectual development. However, castration carried out after puberty and even in mature men with extensive experience in sexual life still leads to a weakening of sexual desire and a deterioration in other sexual functions. If we are talking about the assessment of libido, then during the examination it is necessary to analyze the severity of its various components and, in particular, the safety of its sexual component.

It also provides data on the weakening of sexual desire caused by diabetes mellitus, hypothyroidism, hyperthyroidism, diseases of internal organs, tumors, other diseases and conditions, exposure to ionizing radiation. The author’s clinical observations are given, where the weakening of sexual desire in persons exposed to radiation at the Chernobyl nuclear power plant was preceded by its strengthening. Possible mechanisms for the development of sexual dysfunctions associated with exposure to radiation are reported. Also data on hyposexual sexual desire caused by smoking, alcohol and drugs use are provide.


How to Cite
Kocharyan, G. (2022). Hypoactive Sexual Desire Due to Endocrine Pathology, Diseases of Internal Organs, Tumors, Other Diseases and Conditions, Ionizing Radiation, Smoking, Alcohol, and Drugs. Health of Man, (3), 33–44. https://doi.org/10.30841/2307-5090.3.2022.270815
For practicing physicians
Author Biography

Garnik Kocharyan, Kharkiv Medical Academy of Postgraduate Education

Garnik S. Kocharyan,

MD, PhD, DSc, Professor, Department of Sexology and Medical Psychology


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