Normalization of Kidney Function in Patients with Active Tuberculosis
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Abstract
The objective: to determine the effectiveness of herbal medicine, which includes yarrow, lovage root and rosemary leaves, hepatoprotector with field artichoke and intestinal dialysis (a mixture of electrolytes, macrogol and activated carbon) to normalize kidney function in patients with active tuberculosis (TB).
Materials and methods. During 6 years, 738 patients from 6 till 81 years old with active TB of various localizations, including kidneys, were examined and treated.
We evaluated symptoms, anamnesis, clinical, biochemical tests of blood, urine, glomerular filtration rate, bacteriological analysis, polymerase chain reaction for DNA of Mycobacterium tuberculosis, immunological studies, methods of radiological diagnosis (sonography, radiography, multislice computed tomography, magnetic resonance imaging, radioisotope method), endoscopic research methods with targeted aspiration and biopsy to obtain biological material.
The participants of the research were divided into two groups: main and control ones. Patients in the main group (n=73) were prescribed herbal medicine, which includes yarrow, lovage root and rosemary leaves, hepatoprotector with field artichoke and intestinal dialysis (a mixture of electrolytes, macrogol and activated carbon). The patients in the control group (n=70) used only herbal medicine, which includes yarrow, lovage root and rosemary leaves and hepatoprotector with artichoke.
Variation statistics methods were used to process the obtained data.
Results. According to the result of the study, 68 (93.1%) patients out of 73 persons in the main group with active TB, had symptoms of the improvement. In the control group, only 37 (52.8%) patients reported positive results. In 68 patients of the main group, normalization of renal function was achieved: normalization of blood creatinine levels, glomerular filtration rate, reduction of protein, leukocytes, erythrocyturia.
Conclusions. The proposed method of treatment of patients with active tuberculosis of different localization, including kidneys, on the background of antimycobacterial therapy is one of the possible treatment options. It is proved that normalization of renal function was determined in 93.1% of patients, which is on 40% higher compared to the control group.
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References
World Health Organization. Global tuberculosis report 2021: executive summary [Internet]. Geneva: WHO; 2021. 57 p. Available from: https://www.who.int/publications/i/item/9789240037021
Bellendir EN, Dolgova IB. About the defeats of kidneys at different forms and localizations of tuberculosis. Nephrol. 1993;(3):33–5.
Dolgova IB, Ariel BM. Nonspecific renal lesions in patients with pulmonary tuberculosis. Nephrol. 2002;6(2):28–34.
Kolpakova TA. Medicinal nefropathy in patients with pulmonary tuberculosis with a burdened allergic anamnesis. Tuberculosis Illnesses Lights. 2016;94(10):40–3.
Rassokhin VV, Bobrovickaya TM, Belyacov NA. Kidney damage in HIV infection. Medicinal damage. Diagnostic and treatment issues. 2018;10(2):28–42. doi: 10.22328/2077-9828-2018-10-2-28-42
United Nations Programme on HIV/AIDS. Global HIV & AIDS statistics. Fact Sheet. Geneva: UNAIDS; 2021. 6 p.
Volgina GV, Gadzhikulieva MM. Chronic kidney disease in HIV-ifected patients (causes, diagnosis, management principles). Nephrol Dialysis. 2016;18(3):251.
Yuschuk ND, Volgina GV, Gadzhikulieva MM, Martinov UV, Kocharyan KA. Variants of kidney damage in РШМ infeсtion. Therapeutic archive. 2008;(12):78–81.
Tsentr medychnoyi statystyky Ministerstva okhorony zdorovya. Pokaznyky zakhvoryuvanosti na tuberkuloz ta diyalnist protytuberkul’oznykh zakladiv Ukrayiny za 2019 rik [Internet]. Statystychnyy dovidnyk DZ Tsentr medychnoyi statystyky MOZ Ukrayiny. Kyiv: Tsentr medychnoyi statystyky MOZ Ukrayiny; 2020. Available at: http://medstat.gov.ua/ukr/MMXX.html
Kamyshan IS, Pogrebinskiy VM. Tuberculosis of the urinary organs – Kyiv: Zdorovya; 1987. 184 p.
Kulchavenya EV. Difficulties of diagnostics of tuberculosis of the genitourinary system. Novosibirsk: Jupiter; 2004. 108 p.
Kulchavenya EV, Brizhatyuk EV, Baranchukova AA. Treatment of patients tuberculosis of urinary bladder and prostate (monograph). Chisinau:: LAMBERT Academic Publishing; 2014. 59 p.
Kulchavenya EV. Some questions of phthisiourology (monograph). Chisinau: Lambert Academic Publishing; 2014. 81 p.
Kulchavenya E.V., Krasnov V.A., Mordyk A.V. Almanac of extrapulmonary tuberculosis. Novosibirsk: Sibprint; 2015. 247 p.
Kamyshan IS, Fedun ZV, Stepanov PI. Tuberculosis of the genitals of men and women. Donetsk: Express; 2002. 278 p.
Kamyshan IS. Guide to tuberculosis of the urogenital organs. Kyiv: Nichlava; 2003. 496 p.
Kamishan IS, Heyev YUV, Stepanov PI, Zyablitsev SV, Chornobryvtsiv PA, Reznikov DB ta in., vynakhidnyky. Kamishan IS, Heyev YUV, Stepanov PI, Zyablitsev SV, Chornobryvtsiv PA, Reznikov DB ta in., patentovlasnyky. Sposib diahnostyky urohenital’noho tuberkulezu. Patent Ukrayiny № 33776 O. 2001 Lyut 15.
Brizhatyuk YEV, Kul’chavenya YEV, Baranchukova AA, Cherednichenko AG, Klimova IP. Transrektal’naya punktsionnaya biopsiya prostaty pod ul’trazvukovym kontrolem v diagnostike tuberkuleza prostaty. V: Material VIII mezhreg. nauch.-prakt. konf. urologov Sibiri Innovatsionnyye tekhnologii v urologii. 2009 Maya 28-29; Omsk. Omsk: Omskaya gosudarstvennaya meditsinskaya akademiya Roszdrava RF; 2009. 120 p.
Borovikov VP, Borovikov IP. STATISTICA. Statistical analysis and processing of data in the environment of Windows. A publ. 2th, stereotype. Moskow: Informative-publishing house Filin; 1998. 608 p.
Vlasov VV. Dokazatelnaya meditsina: metody terapii i profilaktiki. Therapia. Ukr med vistnik. 2006;(11-12):52–4.
Ministry of Health of Ukraine. Unified clinical protocol of primary, secondary (specialized) and tertiary (highly specialized) medical care «Tuberculosis» [Internet]. 2014. Order № 620. 2014 September 04. Available at: https://zakon.rada.gov.ua/rada/show/v0620282-14#n20
Ivanova IE. Chronic kidney disease in children and adolescents [Internet]. Chuvashia Health Journal. Issue. 3. 2013. Available at: https://giduv.com/journal/numbers/2013/3/xronicheskaja_bolezn_pochek_u_detej.
Mtvralashvili DA, Veselov VV, Galyaev AV, Veselov VV. Experience in the use of polyethylene glycol preparations for preparation for endoscopic examinations and interventions. General Med. 2016;(3):85–8.
