Cold-sensitive Thermo-TRP-channels as Possible Target in Treatment of Premature Ejaculation: Pilot Study

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Published: Dec 28, 2019
DOI: https://doi.org/10.30841/2307-5090.4.2019.195204
Keywords:
lifelong premature ejaculation, local therapy, receptors of the glans penis, cold sensitive TRP8 ion channels, cooling agent,

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І. І. Горпинченко
State Institution «Institute of Urology of NAMS of Ukraine», Ukraine
А. М. Ситенко
State Institution «Institute of Urology of NAMS of Ukraine», Ukraine
О. В. Жолос
ESC «Institute of Biology and Medicine» of Taras Shevchenko National University of Kyiv, Ukraine

Abstract

An open-label study of the effect of TRPaZS-1 – TRP8 channel activator in gel form in 33 patients with lifelong premature ejaculation. Demonstrated: 1. TRP8 ion channel activator TRPaZS-1 is a promising tool for the treatment of premature ejaculation, which is able to improve statistically and clinically significant parameters of ejaculatory function, as well as erection, libido and orgasm, while reducing the severity of psychoemotional distress. 2. TRPaZS-1 has an acceptable safety profile because it has no systemic adverse effects, and the local ones have a low intensity, are shortlived, and in most cases presented with a feeling of heartburn on the penis. 3. Further studies of the receptors of the penis head, the role of TRP8 ion channels in their functioning, and possible substances for modeling the activity of these channels are needed.

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How to Cite
Горпинченко, І. І., Ситенко, А. М., & Жолос, О. В. (2019). Cold-sensitive Thermo-TRP-channels as Possible Target in Treatment of Premature Ejaculation: Pilot Study. Health of Man, (4), 34–37. https://doi.org/10.30841/2307-5090.4.2019.195204
Issue
No. 4 (2019)
Section
Topical issues
Copyright (c) 2020 І. І. Горпинченко, А. М. Ситенко, О. В. Жолос

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.

Author Biographies

І. І. Горпинченко, State Institution «Institute of Urology of NAMS of Ukraine»

Ihor I. Gorpynchenko,

Head of Department of Sexopathology and Andrology

А. М. Ситенко, State Institution «Institute of Urology of NAMS of Ukraine»

Andrii M. Sytenko,

Department of Sexopathology and Andrology

О. В. Жолос, ESC «Institute of Biology and Medicine» of Taras Shevchenko National University of Kyiv

Oleksandr V. Zholos,

Department of Biophysics and Medical Informatics

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