Results of Program Used for Intracytoplasmic Sperm Injection in In Vitro Fertilization


Ю. М. Гурженко
А. О. Куценко


The work presents the analysis of the effective method for intracystoplasmic sperm injection (ICSI) in the extra corporal fertilization. The study included 180 couples with male infertility factor who had received medical aid in the Institute of Reproductive Medicine (Kyiv) during 2013–2015. The diagnoses were verified, the patients were examined in accordance with the clinical protocols. The ICSI procedure was performed by the common methods. Before the start, the women underwent the course of controlled ovarian stimulation according to the well known classic protocol. The received data were considered taking into account the type of pathospermia (oligoasthenozoospermia, obstructive and non-obstructive azoospermia). As a result of two cycles, the biochemical pregnancy was noted in 97 out of 180 couples (53.9%). But, after the reproductive losses which were the highest between men with non-obstructive azoospermia (14.3% versus 4.5%), the child birth reached 92 (51.1±3.7%), along with group with oligoasthenozoospermia – in 65 out of 120 (54.2±4.5%), obstructive azoospermia in 21 out of 38 (55.3±7.5%), nonobstructive – in 6 out of 22 (27.3±9.0%) the last value was statistically less. This information testifies to the necessity to look for the elevation of the ICSI effectiveness. Nowadays, the most actual in this aspect is considered the improvement of selection criteria for including into the program, with this – the decisive importance belongs to the study of risk factors spectrum which would assure the personified approach to solve the problem.


How to Cite
Гурженко, Ю. М., & Куценко, А. О. (2019). Results of Program Used for Intracytoplasmic Sperm Injection in In Vitro Fertilization. Health of Man, (2), 55–60.
Sexology and andrology
Author Biographies

Ю. М. Гурженко, State Institution «Institute of Urology of NAMS of Ukraine»

Yurii M. Gurzhenko,

Department of Sexopathology and Andrology

А. О. Куценко, State Institution «Institute of Urology of NAMS of Ukraine»

Anton O. Kutsenko


Божедомов В.А. Мужской фактор бездетного брака – пути решения проблемы / В.А. Божедомов // Урология (приложение). – 2016. – № 1. – С. 28–34.

Глыбочко П.В. Половые расстройства у мужчин / П.В. Глыбочко, Ю.Г. Аляев, М.Е. Чалый, Н.Д. Ахвледиани. – М.: МЭОТАР-Медиа, 2012. – С. 71–90.

Концепція Державної програми «Репродуктивне здоров’я нації на 2006–2015 pp.»: Розпорядження Кабінету Міністрів України від 27 квітня 2006 p. № 244-р., Київ. [Електронний ресурс] – Режим доступу: 1 %80

Малышкина А.И. Полиморфизм генов системы детоксикации в супружеских парах, участвующих в программе экстракорпорального оплодотворения / А.И. Малышкина, И.Н. Фетисова, М.А. Липин // Детская медицина Северо-Запада. – 2012. – Т. 3, № 2. – С. 24–26.

Никифоров О.А. Мужское бесплодие: актуальные вопросы физиологии, этиопатогенеза и диагностики нарушений репродуктивной системы у мужчин / О.А. Никифоров, Е.А. Ломейко, С.В. Ломака, И.А. Лавыш // Запорожский мед. журнал. – 2014. – № 4 (85). – С. 69–76.

Нуріманов К.Р. Обґрунтування диференційної діагностики та лікування чоловічої безплідності при обструктивній та необструктивній азооспермії : Автореф. дис. … канд. мед. наук : 14.01.06 – урологія» / К.Р. Нуріманов. – Київ, 2007. – 20 с.

Роживанов Р.В. Стимуляция сперматогенеза у мужчин при патоспермии и бесплодии / Р.В. Роживанов, Н.С. Кравцова, Л.Г. Курбатов // Урология (приложение). – 2016. – № 1. – С. 54–58.

Тимченко О. Рівень безпліддя в областях за даними МОЗ України / О. Тимченко, О.П. Коба, О.В. Личак, Д.О. Микитенко // Медичні перспективи. – 2014. – Т. ХІХ, № 3. – С. 105–111.

Barazani Y. Functional sperm testing and the role of proteomics in the evaluation of male infertility / Y. Barazani, A. Agarwal, E.S.Jr. Sabanegh // J. Urol. – 2014. – V. 84. – P. 255–261.

Bahadur G. First line fertility treatment strategies regarding IUI and IVF require clinical evidence / G. Bahadur, R. Homburg, A. Muneer [et al] // Hum Reprod. – 2016. – V. 31 (6). – P. 1141–6.

Belloc S. How to overcome male infertility after 40: Influence of paternal age on fertility / S. Belloc, A. Hazout, A. Zini, P. Merviel, R. Cabry [et al] // Maturitas. – 2014. – V. 78 (l). – P. 22–29.

Calhaz-Jorge С. Assisted reproductive technology in Europe: results generated from European registers by ESHRE. Preliminary results / C. Calhaz-Jorge, J.A. CastillaAlcala [et al] // Hum Reprod.: Abstracts of the 30th Annual Meeting of the ESHRE, 2014. – P. 54–55.

Cavallini G. Male idiopathic oligoasthenoteratozoospermia / G. Cavallini // Asian J. Androl. – 2006. – V. 8 (2). – P. 143–157.

Check J.H. Failed fertilization with conventional oocyte insemination can be overcome with the ability of ICSI according to binding or failing to bind to the zona pellucida / J.H. Check, A. Bollendorf, C. Wilson // Clin Exp Obstet Gynecol. – 2016. – V. 43 (2). – P. 186–8.

Davies M.J. Reproductive technologies and the risk of birth defects / M.J. Davies, V.M. Moore, K.J. Willson, P. VanEssen [et al] // N. Engl. J. Med. 2012. – V. 366 (19). – P. 1803–1813.

Esteves S.C. Comparison of reproductive outcome in oligozoospermic men with high sperm DNA fragmentation undergoing intracytoplasmic sperm injection with ejaculated and testicular sperm / S.C. Esteves, F. Sánchez-Martín, P. Sánchez-Martín, D.T. Schneider, J. Gosálvez // Fertil Steril. – 2015. – V. 104 (6). – P. 1398–405.

Kavoussi S.K. Live birth following IVF/ICSI using oocytes from donor who was conceived via IVF: a case report / S.K. Kavoussi, K.C. Odenwald, R.B. Summers-Colquitt, P.K. Kavoussi [et al] // J. Assist Reprod Genet. – 2015. – V. 32 (11). – P. 1677–8.

Rpllnr S. Which isolated sperm abnormality is most related to sperm DNA damage in men presenting for infertility evaluation / S. Rpllnr, M. Renkhnlifa, M. Cohen-Rarrie, A. Dalleac [et al] // J. Assist. Reprod. Genet. – 2014. – V. 31 (5). – P. 527–532.

Toftager M. Risk of severe ovarian hyperstimulation syndrome in GnRH antagonist versus GnRH agonist protocol: RCT including 1050 first IVF/ICSI cycles / M. Toftager, J. Bogstad, T. Bryndorf, K. Løssl [et al] // Hum Reprod. – 2016. – V. 31 (6). – P. 1253–64.

Youssef M.A. GnRH agonist for final oocyte maturation in GnRH antagonist co-treated IVF/ICSI treatment cycles: Systematic review and metaanalysis / M.A. Youssef, H.I. Abdelmoty, M.A. Ahmed, M. Elmohamady // J. Adv. Res. – 2015. – V. 6 (3). – P. 341–9.

Zhou J. The effect of first trimester subchorionic hematoma on pregnancy outcomes in patients underwent IVF/ICSI treatment / J. Zhou, M. Wu, B. Wang, X. Hou, J. Wang [et al] // J. Matern Fetal Neonatal Med. – 2016. – V. 28. – P. 1–5.