Shock Wave Therapy in the Treatment of Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Concomitant Erectile Dysfunction
##plugins.themes.bootstrap3.article.main##
Abstract
The objective: evaluation of the effectiveness of shock-wave therapy (SWT) in the complex treatment of men with a non-inflammatory form of chronic pelvic pain syndrome (CPPS) (category IIIB by NIH), complicated by erectile dysfunction.
Materials and methods. 27 patients were examined with a non-inflammatory form of chronic prostatitis/chronic pelvic pain syndrome (category IIIB accordingto NIH), complicated by erectile dysfunction inage from 28 to 45 years. The patients were divided in to two groups: the main group – men who, during the month in addition to the standard treatment, used low-dose shock-wave therapy (SWT) for the perineum area (14 people) using the BTL-6000 SWT TOPLINE device in the mode: frequency – 8 Hz, pressure – 2-3 bar and the control group – men, who were used during the month standard therapy (13 people). Standard therapy for ChP / CPS included: non-steroidal anti-inflammatory drugs, alphablockers, antidepressants or anti-epileptic drugs in standard dosages and regimens.
Results. Patients of the main group showed significant changes after treatment and 2 months after treatment the following indicators: the score on the NIH-CPSI scale decreased by 19,07% and 62,88%; the score according to the ICEF-5 questionnaire increased by 24,54% and 35,79%; the score on the IPSS scale decreased by 10,26% and 43,89%; the volume of the prostate gland decreased by 17,82% and 31,47%, respectively. Patients of the control group showed significant changes after treatment and 2 months after treatment only on the following indicators: the score on the NIH-CPSI scale decreased by 15,16% and 42,83%; the score ont he IPSS scale decreased by 18,68% and 27,21%, respectively; the volume of the prostate gland after therapy and 2 months after treatment decreased by 9,92% and 14,49%. Thus, 2 months after treatment in patients of both groups the manifestations of pain syndrome became slightly pronounced; only in patients of the main group, a violation of erectile function was not detected. A significant decrease in the volume of the prostate gland was observed in patients of the main group.
Conclusion. When using SWT, there was not a single case of significant adverse effect or adverse event. The use of SWT in the complex treatment of men with non-inflammatory form of ChP/CPS complicated by erectile dysfunction is an effective, non-invasive and safe method of physiotherapy.##plugins.themes.bootstrap3.article.details##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.
References
Аксенов П.В. Низкоэнергетическая ударно-волновая терапия в коррекции эректильной дисфункции (обзор литературы) // Здоровье мужчины. – 2014. – № 1. – С. 58–67.
Корнеева О.Ю. Место ударно-волновой терапии в структуре современной реабилитационной стратегии // Современное искусство медицины. – 2013. – № 1. – С. 31–34.
Кульчавеня Е.В., Шевченко С.Ю., Брижатюк Е.В. Экстракорпоральная ударно-волновая терапия при хроническом простатите // Урология. – 2016. – № 2. – С. 77–81.
Крупин В.Н., Крупин А.В., Белова А.Н., Нашивочникова Н.А. Состояние гемодинамики предстательной железы у больных с миофасциальным синдромом // Урологические ведомости. – 2017. – Т. 7, № 4. – С. 39–43.
Руденко И.И., Рапопорт Л.М., Газимиев М.А., Демидко Ю.Л., Байдувалиев А.М. Первый опыт применения ударно-волновой терапии у мужчин с синдромом хронической тазовой боли // Урология. – 2015. – № 6. – С. 26–29.
Терешин А.Т., Неделько Д.Е., Лазарев И.Л. Клинико-функциональное обоснование комбинированного применения ударно-волновой и низкочастотной импульсной электротерапии у больных хроническим простатитом с эректильной дисфункцией // Вестник новых медицинских технологий. – 2014. – Т. 21, № 1. – С. 39–44.
Anothaisintawee T., Attia J., Nickel J.C. Managementof chronic prostatitis/chronic pelvic pain syndrome: asystematic review and network meta-analysis // J. Am. Med. Assoc. – 2011. – Vol. 305 (1). – P. 78–86.
Antolak S.J., Antolak C.M. Chronic pelvic pain:neurogenic or non-neurogenic? Warm detection threshold testing supports a diagnosis of pudendalneuropathy // Pain Physician. – 2018 Mar. – Vol. 21 (2):E125–E135.
Doiron R.C., Tripp D., Tolls V., Nickel J.C. The evolvingclinical picture of chronic prostatitis/chronic pelvicpain syndrome (CP/CPPS): A look at 1310 patients over16 years // Can. Urol. Assoc. J. – 2018 Jun. – Vol. 12 (6).doi: 10.5489/cuaj.4876.
Hatanaka K., Ito K., Shindo T., Kagaya Y., Ogata T., Eguchi K., Kurosawa R., Shimokawa H. Molecular mechanisms of the angiogenic effects of low-energy shock wave therapy: roles of mechanotransduction // Am. J. Physiol. Cell. Physiol. – 2016. – Vol. 311, N 3. – P. C378-385. – doi:10.1152/ajpcell.00152.2016.
Lu Z, Lin G, Reed-Maldonado A, et al. Low-intensity extracorporeal shock wave treatment improves erectile function: a systematic review and meta-analysis. Eur Urol. 2017;71(2):223-233. doi: 10.1016/j.eururo.2016.05.050.
Moayednia A., Haghdani S., Khosrawi S., Yousefi E., Vahdatpour B. Longterm effect of extracorporeal shock wave therapy on the treatment of chronic pelvic pain syndrome due to nonbacterial prostatitis // J. Res.Med. Sci. – 2014 Apr. – Vol. 19 (4). – P. 293–296.
Palmieri A., Imbimbo C., Longo N., Fusco F., Verze P., Mangiapia F., Creta M., Mirone V. A first prospective, randomized, double-blind, placebocontrolled clinical trial evaluating xtracorporeal shock wave therapy for the treatment of Peyronie’s disease // Eur. Urol. – 2009. – Vol. 56, N 2. – P. 363–369. – doi: 10.1016/j.eururo.2009.05.012.
Qi B., Yu T., Wang C., Wang T., Yao J., Zhang X., Deng P., Xia Y., Junger W.G., Sun D. Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of metho-trexate // J. Exp. Clin. Cancer Res. – 2016. – Vol. 35, N 1. – P. 161.
Romeo P., Lavanga V., Pagani D., Sansone V. Extra-corporeal shock wave therapy in musculoskeletal disorders: a review // Med. Princ. Pract. – 2014. – Vol. 23, N 1. – P. 7-13. – doi: 10.1159/000355472.
Sansone V., D’Agostino M.C., Bonora C., Sizzano F., De Girolamo L., Romeo P. Early angiogenic response to shock waves in a three-dimensional model of human microvascular endothelial cell culture (HMEC-1) // J. Biol. Regul. Homeost. Agents. –2012. – Vol. 26, N 1. – P. 29-37.