Physophydesterase Inhibitors of 5 Type and Erective Dysfunction

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Published: Jul 18, 2019
DOI: https://doi.org/10.30841/2307-5090.1.2019.172845
Keywords:
erectile dysfunction, type 5 phosphodiesterase inhibitors, quality of male sexual intercourse,

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Ю. М. Гурженко
State Institution «Institute of Urology of NAMS of Ukraine», Ukraine

Abstract

The article provides an overview of the use of drugs of the phosphodiesterase inhibitor type 5 for the treatment of patients with erectile dysfunction.

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How to Cite
Гурженко, Ю. М. (2019). Physophydesterase Inhibitors of 5 Type and Erective Dysfunction. Health of Man, (1), 64–74. https://doi.org/10.30841/2307-5090.1.2019.172845
Issue
No. 1 (2019)
Section
Sexology and andrology
Copyright (c) 2020 Ю. М. Гурженко

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References

Smith D.G., Frankel S., Yarnell J. Sex and death: are they related? Findings from the Caerphilly cohort study.

Roizen M.F. YOU: Staying Young: The Owner’s Manual for Extending Your Warranty, Mehmet Oz, 2007.

Feldman H.A., Goldstein I., Hatzichristou D.G., Krane R.J., McKinlay J.B. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study // J Urol. 1994. Vol. 151. Р. 54–61.

Johannes C.B., Araujo A.B., Feldman H.A., Derby C.A., Kleinman K.P., McKinlay J.B. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts Male Aging Study // J Urol. 2000. Vol. 163. Р. 460–463.

NIH Consensus Development Panel on Impotence // JAMA. 1993. Vol. 270 (1). Р. 83–90.

Benet A.E., Melman A. The epidemiology of erectile dysfunction // Urol Clin North Am. 1995 Nov. Vol. 22 (4). Р. 699–709. Review. PubMed PMID: 7483123.

Bors E., Comarr A.E. Neurological disturbances of sexual function with special reference to 529 patients with SC spinal cord injury // Urol Surv. 1960. Vol. 10. Р. 191–222.

Krane R.J., Goldstein I., Saenz de Tejada I. Impotence // N Engl J Med. 1989. Vol. 321. Р. 1648–1659.

Bell AS, Palmer MJ. Novel phosphodiesterase type 5 modulators: a patent survey (2008–2010). Expert Opin Ther Pat. 2011;21(10):1631–1641.

Yuan J, Zhang R, Yang Z, et al. Comparative effectiveness and safety of oral phosphodiesterase type 5 inhibitors for erectile dysfunction: a systematic review and network meta-analysis. Eur Urol. 2013;63(5): 902–912.

Glina S, Toscano I, Gomatzky C, et al. Efficacy and tolerability of lodenafil carbonate for oral therapy in erectile dysfunction: a phase II clinical trial. J Sex Med. 2009;6(2):553–557.

Glina S, Fonseca GN, Bertero EB, et al. Efficacy and tolerability of lodenafil carbonate for oral therapy of erectile dysfunction: a phase III clinical trial. J Sex Med. 2010;7(5):1928–1936.

Hatzimouratidis K, Hatzichristou DG. Looking to the future for erectile dysfunction therapies. Drugs. 2008;68(2):231–250.

Doh H, Shin CY, Son M, et al. Mechanism of erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159. Arch Pharm Res. 2002;25(6):873–878.

Paick JS, Kim SW, Yang DY, et al. The efficacy and safety of udenafil, a new selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction. J Sex Med. 2008;5(4):946–953.

Park HJ, Park JK, Park K, Min K, Park NC. Efficacy of udenafil for the treatment of erectile dysfunction up to 12 hours after dosing: a randomized placebo-controlled trial. J Sex Med. 2010;7(6):2209–2216.

Moon DG, Yang DY, Lee CH, et al. A therapeutic confirmatory study to assess the safety and efficacy of Zydena (udenafil) for the treatment of erectile dysfunction in male patients with diabetes mellitus. J Sex Med. 2011;8(7):2048–2061.

Chung BH, Lee JY, Lee SH, Yoo SJ, Lee SW, Oh CY. Safety and efficacy of the simultaneous administration of udenafil and an alpha-blocker in men with erectile dysfunction concomitant with BPH/LUTS. Int J Impot Res. 2009;21(2):122–128.

Zhao C, Kim SW, Yang DY, et al. Efficacy and safety of once-daily dosing of udenafil in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial. Eur Urol. 2011;60(2):380–387.

Paick JS, Kim SW, Park YK, et al. The efficacy and safety of udenafil [Zydena] for the treatment of erectile dysfunction in hypertensive men taking concomitant antihypertensive agents. J Sex Med. 2009;6(11):3166–3176.

Ortaç M, Çayan S, Çalis¸kan MK, et al. Efficacy and tolerability of udenafil in Turkish men with erectile dysfunction of psychogenic and organic aetiology: a randomized, double-blind, placebo-controlled study. Andrology. 2013;1(4):549–555.

Kim BH, Lim HS, Chung JY, et al. Safety, tolerability and pharmacokinetics of udenafil, a novel PDE-5 inhibitor, in healthy young Korean subjects. Br J Clin Pharmacol. 2008;65(6):848–854.

Shim HJ, Kim YC, Park KJ, et al. Pharmacokinetics of DA-8159, a new erectogenic, after intravenous and oral administration to rats: hepatic and intestinal first-pass effects. J Pharm Sci. 2003;92(11):2185–2195.

Walker DK, Ackland MJ, James GC, et al. Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man. Xenobiotica. 1999;29(3):297–310.

Wallis RM, Corbin JD, Francis SH, Ellis P. Tissue distribution of phosphodiesterase families and the effect of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol. 1999;83(5A): 3C–12C.

Francis SH, Turko IV, Corbin JD. Cyclic nucleotide phosphodiesterases: relating structure and function. Prog Nucleic Acid Res Mol Biol. 2001;65:1–52.