A Case of Hyperprogesteronemia in a Young Man


М. Л. Кирилюк
О. Л. Чеканов


The article presents a clinical case of hyperprogesteronemia in a 19-year-old man without visible endocrine and other somatic pathology. Results of laboratory tests: progesterone – 0,441 ng/ml; 0,613 ng/ml (<0,05 –0,149), 17α-hydroxyprogesterone (17α-OHP) – 1,37 ng/ml (0,5 –2,1), DEAS-S – 349; 3 μg/dl (70,2–492,0), androstenedione – 1,21 ng/ml (0,6 –3,1), testosterone (T) total – 21,28 nmol/l (8,64–29,00), T free – 27,93 ng/ml (15–50), estradiol (E2) – 25,28 pg/ml (11,3–43,2), estrone (E1) – 64,9 pg/ml (15,0–65,0), cortisol – 7,37 μg/dl (06:00–10:00; 6,02–18,4), prolactin – 4,91 ng/ml, 2,42 ng/ml (4,04–15,2), lutropin (LH) – 3,2 mIU/ml (1,7–8,6), follitropin (FSH) – 2,6 mIU/ml (1,5–12,4), fasting blood glucose 4,82 mmol/l. This observation is the first in Ukraine described case of hyperprogesteronemia in a healthy young man and is a peculiar phenomenon for further intent study in clinical andrology.


How to Cite
Кирилюк, М. Л., & Чеканов, О. Л. (2018). A Case of Hyperprogesteronemia in a Young Man. Health of Man, (3), 37–39. https://doi.org/10.30841/2307-5090.3.2018.155892
Topical issues
Author Biographies

М. Л. Кирилюк, Ukrainian Research and Practical Centre of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine

Mykhailo L. Kyryliuk,

Head of Department of Neuroendocrinology & General Endocrinology

О. Л. Чеканов, Odesa City Clinical Hospital №10

Oleksandr L. Chekanov,

Department of Human Reproduction


Bookhoff H, et al. Progesterone receptor expression in human prostate cancer: Correlation with tumor progression. Prostate. 2001;48:285–91. https://doi.org/10.1002/pros.1108

Wirth MP, et al. Antiandrogens in the Treatment of Prostate Cancer. European Urology. 2007;51:306–14. https://doi.org/10.1016/j.eururo.2006.08.043

Lee JR. Hormone balance for men. Copyright 2003 by Hormones Etc.

Fadok VA, Lothrop CD Jr, Coulson P. Hyperprogesteronemia associated with Sertoli cell tumor and alopecia in a dog. J Am Vet Med Assoc. 1986 May 1;188(9):1058–9.

Rossmeisl JH Jr, et al. Hyperadrenocorticism and hyperprogesteronemia in a cat with an adrenocortical adenocarcinoma. J Am Anim Hosp Assoc. 2000 Nov-Dec; 36(6):512–17. https://doi.org/10.5326/15473317-36-6-512