Clinical value detection of testicular microlithiasis and recently discovered markers in testicular germ–cell tumors

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Published: Jul 23, 2018
DOI: https://doi.org/10.30841/2307-5090.2.2018.148301
Keywords:
testicular germ cell tumors, immunohistochemical markers, testicular microlithiasis,

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А. В. Сакало
State Institution «Institute of Urology of NAMS of Ukraine», Ukraine

Abstract

Testicular germ-cell tumors (TGCTs) are the most frequent malignant tumors in men 20–40 years of age and the most frequent cause of death in this age group. TGCTs consist of two major groups: seminomas and nonseminomatous germcell tumors (NSGCTs). NSGCTs can be further divided into embryonic carcinoma, teratoma, yolk sac tumor, and choriocarcinoma, which differ in therapy, prognosis, but all show characteristics of the primordial germ cells. New biomarkers potentially represent novel molecular targets for treatment. The role of microRNA is highlighted as molecular prognostic factor in TGCT. Testicular microlithiasis (TM) often detected during examination among men with TGCTs, cryptorchidism, infertility, testicular atrophy and dysgenesis. Patients with TM form a group of risk of development of TGCTs. Also at high risk are patients with infertility, bilateral TM, atrophic and undescended testes and history of TGCTs.

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How to Cite
Сакало, А. В. (2018). Clinical value detection of testicular microlithiasis and recently discovered markers in testicular germ–cell tumors. Health of Man, (2), 27–30. https://doi.org/10.30841/2307-5090.2.2018.148301
Issue
No. 2 (2018)
Section
Topical issues
Copyright (c) 2020 А. В. Сакало

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.

Author Biography

А. В. Сакало, State Institution «Institute of Urology of NAMS of Ukraine»

Anatolii V. Sakalo,

Division of Urologic Oncology

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