Study of treatment effectiveness of patients with chronic nonbacterial prostatitis
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Abstract
The objective: Studying of level of essential microelements (Zinc, Copper, Magnesium, Iron) in blood and ejaculate, specialty of antioxidant and immune defense of the patients with chronic nonbacterial prostatitis and reasoning of polymicroelemental and immunomodulat ing medication use.
Materials and methods. Under supervision were 120 patients with chronic nonbacterial prostatitis, among them 60 patients with inflammatory chronic pelvic pain syndrome (ICPPS – category IIIA) and 60 patients with noninflammatory chronic pelvic pain syndrome (NCPPS – IIIB). Microelements in whole blood and ejaculate were determined using atomic absorption spectrophotometry on C 115 PC. State of antioxidant defense was judged considering quantification of Catalase after A. Bach and S.Zubkova and Superoxide Dismutase. Immune status was analyzed in accordance to the results of determination of the interleukins-6, -8 (IL-6, IL-8) concentration and quantification of tumor necrosis factor-alpha (α-TNF) in blood serum, using the set of company “VECTOR-BEST”, by immunoassay analysis. Correction of violations of bioelemental status and immune defense was conducted by prescription except the standard therapy the polyelemental complex and interferon alpha-2b.
Results. A certain decrease of microelements Zn, Fe, Mg and Cu increase were observed in both groups of patients with chronic nonbacterial prostatitis. Also it was noted that with long duration of chronic nonbacterial prostatitis takes place the antioxidant enzymes level decrease. It was noted a visible concentrations increase of proinflammatory cytokines in blood of both groups of patients with chronic nonbacterial prostatitis. Especially significant increase in serum was IL-8. Under influence of treatment was noted positive dynamics of improve ment of bioelemental consist of blood and ejaculate, increase of antioxidant enzymes level and decrease of proinflammatory cytokines concentration in blood of patients with chronic nonbacterial prostatitis.
Conclusion. With chronic nonbacterial prostatitis was observed decrease of Zinc, Iron, Magnesium and increase of Copper level in blood as well as in ejaculate of the patients. Metabolic changes with shortage of Zn and excess of Cu correlate with antioxidant system disbalance , that is with antioxidant defense level decrease. With chronic nonbacterial prostatitis was observed increase of proinflammatory cytokines concentration, especially in patients with inflammatory chronic pelvic pain syndrome.
Inclusion of polyelemental complex and interferon alpha-2b in complex treatment of the patients with nonbacterial chronic prostatitis improves macro and microelemental status of blood and ejaculate, thereby strengthens antioxidant and immune defense.
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