MicroRNA-508-3p Level in the Blood of Kidney Cancer Patients

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Published: Oct 31, 2017
DOI: https://doi.org/10.30841/2307-5090.3(62).2017.118143
Keywords:
kidney cancer, microRNA, miR-508-3p, marker,

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О. О. Строй
Danylo Halytsky Lviv National Medical University, Ukraine

Abstract

As of today, no marker for kidney cancer (KC) was discovered. Over the last decade, it was found a few microRNAs demonstrating the aberrant expression in various biological fluids of KC patients. Among of them miR-508-3p is one of the potential KC markers.
The aim of our study was to establish the expression of miR-508-3p in the blood of patients with KC and healthy subjects.
Levels of miR-508-3p were quantified in the blood samples of 67 patients with renal cell carcinoma and 64 controls using real-time PCR. The level of this microRNA appeared significantly lower in KC patients compared to controls.
The cut-off level of miR-508-3p in KC is 12.7 relative units.
Sensitivity of miR-508-3p level for KC in our study is 82,% and specificity – 89,6%.
In conclusion, miR-508-3p level in blood can be considered as a possible diagnostic marker of kidney cancer.

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How to Cite
Строй, О. О. (2017). MicroRNA-508-3p Level in the Blood of Kidney Cancer Patients. Health of Man, (3(62), 107–109. https://doi.org/10.30841/2307-5090.3(62).2017.118143
Issue
No. 3(62) (2017)
Section
Oncology
Copyright (c) 2020 О. О. Строй

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Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.

Author Biography

О. О. Строй, Danylo Halytsky Lviv National Medical University

А.А. Stroi

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