MicroRNA-508-3p Level in the Blood of Kidney Cancer Patients


О. О. Строй


As of today, no marker for kidney cancer (KC) was discovered. Over the last decade, it was found a few microRNAs demonstrating the aberrant expression in various biological fluids of KC patients. Among of them miR-508-3p is one of the potential KC markers.
The aim of our study was to establish the expression of miR-508-3p in the blood of patients with KC and healthy subjects.
Levels of miR-508-3p were quantified in the blood samples of 67 patients with renal cell carcinoma and 64 controls using real-time PCR. The level of this microRNA appeared significantly lower in KC patients compared to controls.
The cut-off level of miR-508-3p in KC is 12.7 relative units.
Sensitivity of miR-508-3p level for KC in our study is 82,% and specificity – 89,6%.
In conclusion, miR-508-3p level in blood can be considered as a possible diagnostic marker of kidney cancer.


How to Cite
Строй, О. О. (2017). MicroRNA-508-3p Level in the Blood of Kidney Cancer Patients. Health of Man, (3(62), 107–109. https://doi.org/10.30841/2307-5090.3(62).2017.118143
Author Biography

О. О. Строй, Danylo Halytsky Lviv National Medical University

А.А. Stroi


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