Effectiveness and tolerability of Strondex spray (sildenafil) in patients with erectile dysfunction


І. І. Горпинченко
А. М. Ситенко


The objective: to assess the efficacy and tolerability of Strondex spray (sildenafil) in patients with erectile dysfunction (ED) in the open study.
Patients and methods. 30 men with erectile dysfunction (total EF-IIEF score <17) aged 30 to 65 years with a stable sexual partner and the ability to have at least 2 sexual contacts a week were
included in the study. Patients used Strondex (by spraying into the mouth) for 20–30 minutes before sexual intercourse. The recommended dose of the drug for one use was 25 mg (2 sprays).
Effectiveness of Spray Strondex was assessed by a change in the total score of IIEF and individual domains characterizing erectile function, orgasm, satisfaction with sexual intercourse and sexual life in general after the end of therapy. Tolerance – by frequency, nature and severity of adverse events/reactions.
Results. It was found that Strondex increases the ability of a patient with ED to perform introjection and maintain an erection, which is confirmed by a clinically and statistically significant increase in the average score for the relevant questions (by 1,7–2,2 points) and a total score of EF-IIEF (by 11 points). Strondex is characterized by a satisfactory tolerance: undesirable phenomena during its use included transient tachycardia, flushing, nasal congestion (33,3%) and headache (3,3%).
Conclusion. Strondex can be recommended for the treatment of patients with ED.


How to Cite
Горпинченко, І. І., & Ситенко, А. М. (2017). Effectiveness and tolerability of Strondex spray (sildenafil) in patients with erectile dysfunction. Health of Man, (3(62), 66–70. https://doi.org/10.30841/2307-5090.3(62).2017.117839
Sexology and andrology
Author Biographies

І. І. Горпинченко, ТОВ «Український інститут сексології та андрології», м. Київ

I.I. Gorpynchenko

А. М. Ситенко, ТОВ «Український інститут сексології та андрології», м. Київ

A.M. Sytenko


Горпинченко И.И. Эректильная дисфункция: диагностика и современные методы лечения // Здоровье мужчины. – 2002. – No 1. – С. 9–11.

Горпинченко И.И., Мирошников Я.О. Эректильная дисфункция. – Л.: Медицина світу, 2003.

Сексология и андрология / Под ред. А.Ф. Возианова, И.И. Горпинченко. – К.: Абрис, 1997. – 880 с.

Capogrosso P., Colicchia M, Ventimiglia E, Castagna G, Clementi MC, Suardi N, Castiglione F, Briganti A, Cantiello F, Damiano R, Montorsi F, Salonia A. One patient out of four with newly diagnosed erectile dysfunction is a young man-worrisome picture from the everyday clinical practice. J Sex Med. 2013 Jul;10(7):1833–41.

Hatzimouratidis K., Hatzichristou D. Phosphodiesterase type 5 inhibitors: unmet needs //Curr. Pharm. Des. 2009; 15 (30): 3476–85.

Jiann B.P., Yu C.C., Su C.C., Tsai J.Y. Compliance of sildenafil treatment for erectile dysfunction and factors affecting it. Int J Impot Res. 2006 MarApr;18(2):146–9.

Drewes SE, George J, Khan F. Recent findings on natural products with erectile-dysfunction activity // Phytochemistry. 2003 Apr; 62(7): 1019–25.

Методичні рекомендації з клінічних випробувань лікарських засобів в Україні. – К.: МОРІОН, 1999. – С. 1–74.

Capelleri J.C., Rosen R.C., Smith M.D., Quirk F., Maytom M.C., Mishra A., Osterloh I.H. Some developments on the International Index of Erectile Dysfunction (IIEF) // Drug Information Journal, 1999. – Vol. 33. – Р. 179–190.

Rosen R.C., Riley A., Wagner G. et al. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction // Urology. – 1997. – V. 49. – P. 822–830.

Ang H.H., Ngai T.H., Tan T.H. Effects of Eurycoma longifolia Jack on sexual qualities in middle aged male rats. Phytomedicine. 2003;10:590–593.