The influence of the drug Prostex on indices of erectile function in patients with symptomatic benign prostatic hyperplasia
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Abstract
The objective: to evaluate the effect of the drug on Prosteks indicators characterizing the severity of LUTS (IPSS, QoL) and erectile dysfunction (MIEF5, hardness of erection), in sexual active patients with symptomatic BPH.
Patients and methods. In an open study of 30 sexually active patients with symptomatic BPH aged 45–55 years examined the efficacy and tolerability of Prosteks (1 rectal suppository at night for 30 days). The main performance indicators: IPSS, QoL, MIEF5, hardness of erection, minor: Qmax, PVR.
Results. It was found 30 days course Prosteks sexual active patients with symptomatic BPH and ED statistically and clinically significant effect on the total score of IPSS, QoL, total score MIEF5, Ball erection hardness. Prosteks effective in patients with mild to moderate urinary disorders caused by BPH, confirmed by a decrease in the proportion of patients with a moderate degree of impairment in its reception from 90% to 53.3%. Prosteks improves erectile function, as manifested lessening the severity of ED and increased the proportion of patients (50%), which evaluate the rigidity of erection as the maximum. Application Prosteks within 1 month does not affect the residual urine volume, prostate and PSA, and the effect of increasing Qmax has no clinical significance.
Conclusions. The results of the study give reason to recommend Prosteks for the treatment of patients with symptomatic BPH and ED with mild to moderate symptoms. Further studies are needed to determine the mechanisms underlying the clinical effects Prosteks, and whether it should be combined with uroselective alpha-blockers in severe bladder outlet obstruction.
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