Experience of hyaluronic acid in men with chronic pelvic pain syndrome on the background of interstitial cystitis
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Abstract
In SI «Institute of Urology of NAMS of Ukraine» was observed 61 male with chronic pelvic pain syndrome (CPPS) associated with interstitial cystitis (IC). The first group (n=30) consisted of persons with this diagnosis, treated with intravesical hyaluronic acid (HA, Instilan ® drug production «Yuri Farm», Ukraine), a course of 6 instillations - in the first month 1 time per week, then 1 times month No 2. The control group (n=31) were similar to patients treated with intravesical DMSO mixture (20% – 10 ml) of 2% – 10,0 ml of lidocaine, 1 time per week, the course of 12 instillations. The average age of study 46,2±1,1 years, history of disease duration – 2,2±0,4 years.
It has been found that the use of HA as intravesical instillation in men with ITs it is a highly effective method of treatment. Comparison of the results of treatment of established development of persistent remission in patients with IC in the application of GC (62,2%), which was almost 1.8 times better than the results of a similar therapy with DMSO with lidocaine (34,8%). The effectiveness of therapy GK manifested in symptoms regression in terms of 6 and 12 months by 37,9% and 47,2% (in the control – by 25,9% and 28,7%, respectively; p<0,05). Therapy with GC (Instilan ®) characterized by a lower frequency of refusal of treatment by patients – 3,3%, in contrast to the individual group II (25,8%), where the risk of adverse events at the time of treatment was significantly higher.
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References
Воропай А.Ю. Особенности диагностики и лечения интерстициального цистита // Болезни и антибиотики. – 2009. – No 1 (1).
Иванов Д.Д., Домбровский Я.А. Применение препаратов гиалуроновой кислоты в терапии хронического цистита // Новости медицины и фармации. – 2015. – No 8 (539). – С. 12–13.
Интерстициальный цистит – современный взгляд на проблему / А.С. Переверзев // Международный медицинский журнал. – 2008. – Т. 14, No 1. – С. 114–123.
Лоран О.Б., Зайцев А.В., Липский В.С. Диагностика и лечение интерстициального цистита у женщин. – Саратов: Приволжское книжное изд-во, 2001. – 190 с.
Основные направления диагностики и лечения интерстициального цистита / А.Ю. Воропай // Международный медицинский журнал. – 2005. – Т. 11, No 2. – С. 115–118.
Пасечников С.П., Шило В.Н. Применение гиалуроновой кислоты – эффективная опция лечения лучевого геморрагического цистита // Медицинские аспекты здоровья мужчины. – 2016. – No 1 (20). – С. 42–46.
Barua JM, Arance I, Angulo JC, Riedl CR. A systematic review and meta-analysis on the efficacy of intravesical therapy for bladder pain syndrome/interstitial cystitis. Int Urogynecol J. 2016 Aug;27(8):1137–47.
Cervigni M., Sommariva M., Tenaglia R. et al. A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl
sulfoxide in women with bladder pain syndrome/interstitial cystitis. Neurourol Urodyn. 2016 Sep 21. doi:10.1002/nau.23091. [Epub ahead of print] PubMed PMID: 27654012].
Cicione A., Cantiello F., Ucciero G. Et al. Intravesical treatment with highlyconcentrated hyaluronic acid and chondroitin sulphate in patients with recurrent urinary tract infections: Results from a multicentre survey. Can Urol Assoc J. 2014 Sep;8(9–10).
Costantini E., Lazzeri M., Pistolesi D. et al. Morphological changes of bladder mucosa in patients who underwent instillation with combined sodium hyaluronic acid-chondroitin sulphate (Ialuril®). Urol Int. 2013;91(1):81–8.
Curhan G.C., Speizer F.E., Hunter D.J. Epidemiology of interstitial cystitis: a population based study // The journal of urology. – 1999. – Vol. 161. – P. 549–552.
Engeler D., Baranowski A.P., Borovicka J., Cottrell A., Dinis-Oliveira P. et al. Guidelines on Chronic Pelvic Pain. European Association of Urology, 2014.
Fidan K., Büyükkaragöz B., Özen O., Demirogullari B., Söylemezoglu O. The use of intravesical hyaluronic acid for recurrent urinary tract infections in children: a case-series study. Ren Fail. 2015 Nov;37(10):354–8.
Gacci M., Saleh O., Giannessi C. et al. Bladder Instillation Therapy With Hyaluronic Acid and Chondroitin Sulfate Improves Symptoms of Postradiation Cystitis: Prospective Pilot Study. Clin
Genitourin Cancer. 2016 Oct;14(5):444–449.
Gao Y., Liao L. Intravesical injection of botulinum toxin A for treatment of interstitial cystitis/bladder pain syndrome: 10 years of experience at a single center in China. Int Urogynecol J. 2015 Jul;26(7):1021–6.
Gülpinar O., Haliloğlu A.H., Gökce M.Э., Arikan N. Instillation of Hyaluronic Acid via Electromotive Drug Administration Can Improve the Efficacy of Treatment in Patients With Interstitial Cystitis/ Painful Bladder Syndrome: A RandomizedProspective Study. Korean J Urol. 2014 May;55(5):354–9.
Jocham D., Froehlich G., Sandig F., Ziegler A. The care situation of patients with interstitial cystitis in Germany: results of a survey of 270 patients. Urologe A. 2013 May;52(5):691–702.
Nickel J.C., Downey J., Morales A., Emerson L., Clark J. Relative efficacy of various exogenous glycosaminoglycans in providing a bladder surface permeability barrier. J Urol. 1998 Aug;160(2):612–4.
Pazin C., de Souza Mitidieri A.M., Silva A.P. et al. Treatment of bladder pain syndrome and interstitial cystitis: a systematic review. Int Urogynecol J. 2016 May;27(5):697–708.
Pyo JS, Cho WJ. Systematic Review and Meta-Analysis of Intravesical Hyaluronic Acid and Hyaluronic Acid/Chondroitin Sulfate Instillation for Interstitial Cystitis/Painful Bladder Syndrome. Cell Physiol Biochem. 2016;39(4):1618–25.
Riedl C.R., Engelhardt P.F, Daha K.L., Morakis N., Pflüger H. Hyaluronan treatment of interstitial cystitis/painful bladder syndrome. Int Urogynecol J Pelvic Floor Dysfunct. 2008 May;19(5):717–21.
Tareen B.U., Bui D., McMahon D.R., Nasrallah P.F. Role of positional instillation of contrast cystography in the algorithm for evaluating children with confirmed pyelonephritis. Urology. 2006 May;67(5):1055–7.
Thompson A., Adamson A., Bahl A., Borwell J. et al. Guidelines for the diagnosis, prevention and management of chemical- and radiation-induced cystitis. British Association of Urological Surgeons // Journal of Clinical Urology. – 2014. – Vol. 7, no. 1: 25–35.
Toft B.R., Nordling J. Recent developments of intravesical therapy of painful bladder syndrome/interstitial cystitis: a review. Curr Opin Urol. 2006. Jul;16(4):268–72.
Wyndaele J.J., Van Dyck J., Toussaint N. Cystoscopy and bladder biopsies in patients with bladder pain syndrome carried out following ESSIC guidelines. Scand J Urol Nephrol. 2009;43(6):471–5.
Zubkowski T., Jurkiewicz B., Saracyn M. Treatment of Recurrent Bacterial Cystitis by Intravesical Instillations of Hyaluronic Acid. Urol J. 2015 Jul 1;12(3):2192–5.