Experience of hyaluronic acid in men with chronic pelvic pain syndrome on the background of interstitial cystitis
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Abstract
In SI «Institute of Urology of NAMS of Ukraine» was observed 61 male with chronic pelvic pain syndrome (CPPS) associated with interstitial cystitis (IC). The first group (n=30) consisted of persons with this diagnosis, treated with intravesical hyaluronic acid (HA, Instilan ® drug production «Yuri Farm», Ukraine), a course of 6 instillations - in the first month 1 time per week, then 1 times month No 2. The control group (n=31) were similar to patients treated with intravesical DMSO mixture (20% – 10 ml) of 2% – 10,0 ml of lidocaine, 1 time per week, the course of 12 instillations. The average age of study 46,2±1,1 years, history of disease duration – 2,2±0,4 years.
It has been found that the use of HA as intravesical instillation in men with ITs it is a highly effective method of treatment. Comparison of the results of treatment of established development of persistent remission in patients with IC in the application of GC (62,2%), which was almost 1.8 times better than the results of a similar therapy with DMSO with lidocaine (34,8%). The effectiveness of therapy GK manifested in symptoms regression in terms of 6 and 12 months by 37,9% and 47,2% (in the control – by 25,9% and 28,7%, respectively; p<0,05). Therapy with GC (Instilan ®) characterized by a lower frequency of refusal of treatment by patients – 3,3%, in contrast to the individual group II (25,8%), where the risk of adverse events at the time of treatment was significantly higher.
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