To identify negative prognostic factors which influence survival in pts with disseminated seminoma in the favorable and intermediate prognostic group. Analyzed the results of treatment of the 27 patients with disseminated seminoma who had received chemotherapy at our department by modern chemotherapy regimen (EP ± bleomycin). With median follow-up 74 (3,5-96,9) months, 5-year OS rate was 85,2%. Only stage of the disease was identify as negative prognostic factors associated with progression and OS (р=0,05, р<0,0005). Prospective part of the study will include intensification of chemotherapeutical regiments by using 4PEB in pts with disseminated seminoma in intermediate prognostic group.
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