Newly discovered immunohistochemical markers and micro-RNAs detected in testicular germ–cell tumors

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А. В. Сакало
П. Г. Яковлєв

Abstract

Testicular germ-cell tumors (TGCTs) are the most frequent malignant tumors in men 20–40 years of age and the most frequent cause of death in this age group. TGCTs consist of two major histological groups: seminomas and nonseminomatous germ-cell tumors (NSGCTs). NSGCTs can be further divided into embryonic carcinoma, teratoma, yolk sac tumor, and choriocarcinoma, which differ in therapy, prognosis, but all show characteristics of the primordial germ cells. New biomarkers – OCT3/4, SOX2, SOX17, HMGA1, Nek2, GPR30 – represent novel molecular targets for antineoplastic strategies. The role of micro-RNA is highlighted as molecular prognostic factor in patients with TGCT.

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How to Cite
Сакало, А. В., & Яковлєв, П. Г. (2016). Newly discovered immunohistochemical markers and micro-RNAs detected in testicular germ–cell tumors. Health of Man, (1(56), 24–26. https://doi.org/10.30841/2307-5090.1(56).2016.95378
Section
Topical issues
Author Biography

А. В. Сакало, ДУ «Інститут урології НАМН України», м. Київ

Сакало Анатолий Валериевич

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