Cовременные иммуногистохимические маркеры и микро-РНК при герминогенных опухолях яичка

А. В. Сакало, П. Г. Яковлєв

Аннотация


Герминогенные опухоли яичка чаще встречаются в возрасте 20–40 лет и являются одной из основных причин смерти от онкологических заболеваний в указанной возрастной группе. В статье рассмотрены новые иммуногистохимические маркеры: OCT3/4, SOX2, SOX17, HMGA1, Nek2, GPR30. Также освещена роль исследования микроРНК в качестве молекулярного прогностического маркера герминогенных опухолей яичка.

Ключевые слова


иммуногистохимические маркеры; микро-РНК; опухоли яичка

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Литература


Gilligan TD. American Society of Clinical Oncology Clinical Practice Guideline on uses of serum tumor markers in adult males with germ cell tumors / TD. Gilligan, J. Seidenfeld, EM. Basch [et al.] // J.Clin.Oncol. 2010 Jul 10;28(20):3388–404.

Barlow L. Serum tumor markers in the evaluation of male germ cell tumors / L. Barlow, G. Badalato, J. McKiernan // Nat Rev Urol. 2010 Nov;7(11):610–7.

Krege S. The role of tumour markers in diagnosis and management of testicular germ cell tumours / S. Krege, P. Albers, A. Heidenreich // Urologe A. 2011 Mar;50(3):313–21.

Neumann A. Human placental alkaline phosphatase (hPLAP) is the most frequently elevated serum marker in testicular cancer / A. Neumann, T. Keller, D. Jocham, C. Doehn // Aktuelle Urol. 2011 Sep;42(5):311–5.

Gilligan T. American Society of Clinical Oncology. American Society of Clinical Oncology Clinical Practice Guideline on uses of serum tumor markers in adult males with germ cell tumors / T.Gilligan, J. Seidenfeld, E.Basch [et al.] // J Clin Oncol. 2010 Jul 10;28(20):3388–404.

Syring I. Circulating serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as biomarkers in patients with testicular germ cell cancer / I. Syring, J. Bartels, S. Holdenrieder [et al.] // J Urol. 2015 Jan;193(1):331–7.

Ulbright TM. The most common, clinically significant misdiagnoses in testicular tumor pathology, and how to avoid them / TM. Ulbright // Adv Anat Pathol. 2008 Jan;15(1):18–27.

Cleynen I, The HMGA proteins: a myriad of functions (Review) / V. Cleynen, W. Van de Ven // Int J Oncol. 2008 Feb;32(2):289–305.

Pallante P. High mobility group a proteins as tumor markers / P. Pallant, R. Sepe, F. Puca, A. Fusco // Front Med. 2015 Mar 25;2:15.

Chieffi P. Recent advances in molecular and cell biology of testicular germcell tumors / P. Chieffi // Int Rev Cell Mol Biol. 2014;312:79–100.

Chieffi P. An update on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors / P. Chieffi, S. Chieffi // Histol Histopathol. 2014 Aug;29(8).

Barbagallo F, Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas / F. Barbagallo, M. Paronetto, R. Franco [et al.] //J Pathol. 2009 Feb;217(3):431–41.

Naro C. The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival / C. Naro, F. Barbagallo, Chieffi [et al.] // Nucleic Acids Res. 2014; 42, 3218–3227.

Looijenga L. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors / L. Looijenga, H. Stoop, H.de Leeuw [et al.] // Cancer Res. 2003 May 1; 63(9):2244–50.

Gillis A. Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis / A. Gillis, H. Stoop, K. Biermann [et al.] // Int J Androl. 2011 Aug;34(4 Pt 2):e160–74.

Dieckmann K, MicroRNAs miR-371-3 in serum as diagnostic tools in the management of testicular germ cell tumours / K. Dieckmann, M. Spiekermann, T. Balks [et al.] // Br J Cancer. 2012 Nov 6;107(10):1754–60.

Spiekermann M. MicroRNA miR371a-3p in serum of patients with germ cell tumours: evaluations for establishing a serum biomarker / M. Spiekermann, G. Belge, N. Winter [et al.] // Andrology. 2015 Jan;3(1):78–84.

Rounge T. Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs / T. Rounge, K. Furu, R. Skotheim [et al.] // Mol Cancer. 2015 Aug 12;14:153.

Spiekermann M. Is relative quantification dispensable for the measurement of microRNAs as serum biomarkers in germ cell tumors? / M.Spiekermann, K. Dieckmann, T.Balks [et al.] // Anticancer Res. 2015 Jan;35(1):117–21.

Syring I. Circulating serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as biomarkers in patients with testicular germ cell cancer / I.Syring, J.Bartels, S. Holdenrieder [et al.] // J Urol. 2015 Jan;193(1):331–7.

Rijlaarsdam M, Identification of known and novel germ cell cancer-specific (embryonic) miRs in serum by highthroughput profiling / M. Rijlaarsdam, T. van Agthoven, A. Gillis [et al.] // Andrology. 2015 Jan;3(1):85–91.

Carthew R, Origins and Mechanisms of miRNAs and siRNAs / R. Carthew, E. Sontheimer // Cell. 2009 Feb 20;136(4):642–55.

Farazi T. MiRNAs in human cancer / T. Farazi, J. Spitzer, P. Morozov, T. Tuschl // J Pathol. 2011 Jan;223(2):102–15.

Bartel D. MicroRNAs: genomics, biogenesis, mechanism, and function / D. Bartel // Cell. 2004 Jan 23;116(2):281–97.

Esquela-Kerscher A. Oncomirs microRNAs with a role in cancer / A. Esquela-Kerscher, F. Slack // Nat Rev Cancer. 2006 Apr;6(4):259–69.

Farazi TA. miRNAs in human cancer / TA. Farazi, JI. Spitzer, P. Morozov, T. Tuschl // J Pathol. 2011, 223, 102–115.

Catto J. MicroRNA in prostate, bladder, and kidney cancer: a systematic review / J. Catto, A. Alcaraz, А. Bjartell [et al.] // Eur Urol. 2011 May;59(5):671–81.

Gillis A. High throughput microRNAome analysis in human germ cell tumors / A. Gillis Stopp H, R Hermus, J. Oosterhuis [et al.] // J Pathol. 2007, 213, 319–328.

Palmer R. Children’s Cancer and Leukaemia Group. Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets / R. Palmer, M. Murray, H. Saini [et al.] // Cancer Res. 2010 Apr 1;70(7):2911–23.

Gillis A. Targeted serum miRNA(TSmiR) test for diagnosis and follow-up of testicular germ cell cancer patients: a proof of principle / A.Gillis, M.Rijlaarsdam, R.Eini [et al.] // Mol Oncol. 2013 Dec;7(6):1083–92.

Ruf C. Small RNAs in the peripheral blood discriminate metastasized from non-metastasized seminoma / C. Ruf, D. Dinger, M. Port [et al.] // Mol Cancer. 2014 Mar 6;13:47.




DOI: https://doi.org/10.30841/зм.v0i1 (56).95378

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