DOI: https://doi.org/10.30841/зм.v0i2 (57).82981

Определение анти-Hsp60 антител в сыворотке крови больных раком предстательной железы

В. М. Григоренко, Л. Ф. Яковенко, М. В. Вікарчук, Р. О. Данилець, М. О. Косюхно, І. В. Крупська, Л. Л. Сидорик

Аннотация


В статье приведены данные относительно уровня анти-Hsp60 aнтител в сыворотке крови 55 больных раком предстательной железы, которым была выполнена радикальная простатэктомия. В качестве контроля использовали низкореактивную к Hsp60 сыворотку доноров крови (n=67). Установлено статистически достоверное различие между уровнем анти-Hsp60 антител у больных раком предстательной железы и контролем. Не обнаружено корреляции уровня анти-Hsp60 антител с клинико-морфологическими характеристиками больных: стадия, уровень простатспецифического антигена (ПСА), показатель Глисона. Высокие уровни анти-Hsp60 антител в сыворотке наблюдали, как правило, у больных с агрессивным течением заболевания. У пациентов с низким дооперационным уровнем ПСА, но у которых развился биохимический рецидив после радикальной простатэктомии, уровень анти-Hsp60 антител был повышенным (анти-Hsp60 положительная сыворотка).

Ключевые слова


рак предстательной железы; наблюдение

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Литература


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