Efficiency of Nimesil in the case of chronic prostatitis/chronic pelvic pain syndrome in men
Keywords:chronic prostatitis with chronic pelvic pain syndrome, nonspecific anti-inflammatory agents, results of treatment
AbstractThe aim of the study: to study the efficacy of one of not steroid antiinflammatory drugs (NSAIDs) class sulfonamide nimesulide (Nimesil) among middle-aged men with CP/CPPS. Materials and methods. A study was conducted on a selective competitive inhibitor cycloxygenase-2 nimesulide 88 among middle-aged men with CP/CPPS. Group 1 (n=40) consisted of patients who were assigned to levofloxacin 500 mg 2 times a day. Group 2 (n=48) included men who received levofloxacin 500 mg 2 times a day and Nimesil (company Berlin-Chemie AG, Germany) по100 mg 2 times a day for 3 weeks. To obtain objective symptoms at baseline and after 3 weeks of treatment used the International scale prostatic symptoms (IPSS) and the index of the symptoms of prostatitis the National institutes of health (NIH-CPSI). Results. The mean change in total IPSS in comparison with the initial, was higher in group 2 than in group 1 (group 1 and 1.1, group 2 and 4.3; p<0.05). Significant improvement was noted in subscale urination index IPSS (group 1 and 0.7, group 2 is 3.0; p <0.05). Change of index the NIH-CPSI in group 2 was significantly more pronounced than in group 1 (group 1 3, 2-group 2 7,2; p <0,05). Significant changes were noted in the domains of urination (group 1 0.5, and group 2 1,7; p<0.05) and quality of life (group 1 1.0 for group 2 and 1.8; p<0.05) index of the NIH-CPSI. Conclusion. Nimesil (100 mg 2 times a day was well tolerated and significantly improved symptoms of CP/CPPS in men of middle age. Nimesil can be a useful drug for the treatment of CP/CPPS as a monotherapy and in combination with other drugs for empirical therapy.
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