DOI: https://doi.org/10.30841/2307-5090.2(57).2016.82941

Improving the efficiency of the treatment of chronic nonspecific prostatitis, complicated excretory-toxic sterility

О. Д. Нікітін

Abstract


It is known that the treatment of inflammatory diseases of the prostate followed by prolonged use of antibacterial drugs that have spermtoxic and immunosuppressive activity. Therefore, relevance of the search of new opportunities for safe and effective treatment of excretory-toxic infertility is undeniable. The objective: to evaluate the efficacy and safety of the treatment of patients with chronic nonspecific prostatitis, complicated excretorytoxic sterility using Pravenor® Forte. Patients and methods. Clinical and laboratory examination of 72 patients with chronic nonspecific prostatitis in which, according to the semen, showed signs of excretory-toxic infertility. 37 patients of the main group rate admission Pravenor® Forte was held along with the traditional treatment. Results. Patients of the main group recorded a more pronounced clinical effect. In particular, 10 days after the onset of disease symptoms disappeared algic in 31 (83,7%) patients in the main group and 23 (65,8%) the comparison group, dysuria – respectively in 16 (43,2%) and 10 (28,6%), discomfort in the urethra – 14 (37,8%) and 9 (25,7%). Microscopic study of prostate secretions before and after treatment showed a significant decrease in leukocyte reaction in the main group – with 84,3±6,1 to 14,1±1,7, in the comparison group – with 79,7±5,5 to 16,1±4,1. Conclusion. Combined therapy with Pravenor® Forte in patients with chronic nonspecific prostatitis, complicated excretory-toxic sterility, shown to be effective in 94.6% of patients, as evidenced by significant changes of parameters of sperm concentration, motility and maintenance of pathological forms.

Keywords


male sterility; Pravenor® Forte; treatment

References


Analiz osnovnih pokaznikiv zdorov’ja naselennja Ukrai'ni za 1995–2000 rr. – K.: MOZ Ukrai'ni, Centr med. statistiki, 2001. – 138 s.

Antispermal'nye antitela i ih rol' v vozniknovenii immunologicheskogo besplodija/ Ju. Aljaev, M. Gazimiev, E. Shestakova, S. Alenov //Vrach. – 2008. – № 7. – S. 29–30.

Bojko M.I. Ekskretorno-toksichna forma nepliddja u cholovikiv: rol' glutationovoi' antioksidantnoi' sistemi v biologichnij povnocinnosti spermatozoi'div / Bojko M.I., Vorobec' D.Z. // Klinich. ta eksperimental'na patologija. – 2005. – T. 4, № 3. – S. 110–114.

Bojko N.I., Dobrovol'skaja L.I. Muzhskoe besplodie pri hlamidijnoj genital'noj infekcii //Zdorov'e muzhchiny. – 2003. – № 5. – S. 100–104.

Bojko M.I. Cholovicha bezplidnist' // Nova medicina. – 2002. – № 4. – S. 36–39.

Godlevskij D.N. Varikocele ne detskaja bolezn'?/ D.N. Godlevskij, A.B. Okulov, E.A. Volod'ko //Andrologija i genital'naja hirurgija. – M., 2008. – № 2. – S. 85–91.

Gorpinchenko I.I. Analiz gendernyh problem pri supruzheskom besplodii / Gorpinchenko I.I., Romashhenko O.V., Nurimanov K.R. // Zdorov'e muzhchiny. – 2004. – № 1 (8). – S. 14–17.

Gorpinchenko I.I. Klinicheskie issledovanija v oblasti zhenskoj seksologii: rezul'taty i perspektivy/ I.I. Gorpinchenko, O.V. Romashhenko, S.N. Mel'nikov //Zdorov'e muzhchiny. – 2005. – № 1. – S. 35–37.

Gorpinchenko I.I. Social'no-gigienicheskie aspekty seksual'nogo zdorov'ja naselenija Ukrainy/ I.I. Gorpinchenko, M.I. Sokolova //Ohorona zdorov’ja Ukrai'ni: – 2003. – № 3. – S. 17–21.

Gorpinchenko I.I. Seksual'nye rasstrojstva pri nevrozah u muzhchin/ I.I. Gorpinchenko //Zhurnal praktichnogo likarja. – K., 2001. – № 2. – S. 8–13.

Zachepilo A.V. Osobennosti jetiologii i patogeneza narushenij funkcii muzhskoj reproduktivnoj sistemy, obuslovlennyh jekologicheskimi faktorami / A.V. Zachepilo, S.B. Argifeksov // Probl. reprodukcii. – 2007. – T. 13, № 4. – S. 76.

Znachimost' «atipichnyh» infekcij, peredajushhihsja polovym putem v jetiopatogeneze hronicheskogo prostatita / D.N. Velichko, A.A. Erkovich, D.D. Cyrendorzhiev i dr. // Andrologija i genital'naja hirurgija. – 2008. – № 1. – S. 17–22.

Loran O.B., Segal A.S. Hronicheskij prostatit // Sb. nauch. tr. 10 Rossijskogo s#ezda urologov. – M., 2002. – S. 209–222.

Mel'nichenko G.A., Pronin V.S., Romancova T.I. i dr. Klinika i diagnostika gipotalamo-gipofizarnyh zabolevanij (ucheb.-metod. posobie). – M.: Triada, 2005. – 98 s.

Nurimanov K.R. Analiz efektivnosti ta bezpechnosti metodik diagnostiki cholovichoi' bezplidnosti pri azoospermii' // Zdorov'e muzhchiny. – 2006. – № 3. – S. 105–112.

Osnovy reproduktivnoj mediciny: Prakticheskoe rukovodstvo / Pod red. V.K. Chajki. – Doneck: OOO «Al'mateo», 2001.

Pershukov A.I. Varikocele i nekotorye voprosy muzhskogo besplodija. – K.: Sputnik-1. – 2002. – 256 s.

Pomerancev O.N. Jeffektivnost' kompleksnoj terapii urogenital'noj hlamidijnoj infekcii u bol'nyh reproduktivnogo vozrasta: avtoref. dis. ... kand. med. nauk/ 14.00.11 – kozhnye i venericheskie bolezni / Pomerancev Oleg Nikolaevich. – M., 2008. – 21 s.

Pochernikov D.G., Semenchikov S.A., Strel'nikov A.I. Gormonal'nyj profil' muzhchin s patozoospermiej // Andrologija i genital'naja hirurgija. – 2008. – № 2. – S. 98.

Problemy diagnostiki immunologicheskoj prichiny muzhskogo besplodija / V.A. Bozhedomov, Solov'ev A.A. Osobennosti morfo-funkcional'nyh izmenenij jaichek u pacientov s kriptorhizmom/ A.A. Solov'ev, A.F. Astrahancev, E.A. Bajroshevskaja //Andrologija i genital'naja hirurgija. – M., 2008. – № 2. – S. 52–54.

Sytenko A.M. Nekotorye social'nofiziologicheskie prichiny besplodija supruzheskoj pary. Est' li perspektiva dal'nejshego sushhestvovanija chelovechestva?/ A.M. Sytenko //Zdorov'e muzhchiny. – 2007. – № 2. – S. 194–199.

Stojka B.R. Morfofunkcional'na harakteristika spermatozoi'div pri porushenni fertil'nosti: Avtoref. dis. ... kand. med. nauk: 14.03.09 – gistologija, citologija, embriologija. – K., 2005. – 20 s.

Reproduktivnaja funkcija u bol'nyh hronicheskim abakterial'nym prostatitom // V.V. Evdokimov, V.I. Erasova, E.V. Orlova i dr. // Urologija. – 2006. – № 2. – S. 68–69.

Solov'ev A.A. Osobennosti morfofunkcional'nyh izmenenij jaichek u pacientov s kriptorhizmom/ A.A. Solov'ev, A.F. Astrahancev, E.A. Bajroshevskaja //Andrologija i genital'naja hirurgija. – M., 2008. – № 2. – S. 52–54.

Hadziselimovic F. Cryptorhidism. It s Ympact on Male Fertility //Evropean Urology, 2002; 41 (2): 121–123.

Helmerharst F.M., Finken M.J.J., Erwich J.J. Antisperm antibodies Detection assays for antisperm antibodies: what do they test? // Hum Reprod. 1999. – Vol. 14. – P. 1669–1671.

Jarow J.P. Endocrine causes of male infertility / J.P. Jarow // Ural. Ctin. N.A. – 2003. – Vol. 30. – P. 640–645.

WHO. Manual for the standardized investigation and diagnosis of the infertile couple. – WHO, 3th ed. Cambridge universiti press, 2000. – 103 r.




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