Randomized Clinical Trial to Evaluate the Effect of Canephron N in Comparison to Ciprofloxacin in the Prevention of Postoperative Lower Urinary Tract Infections after Midurethral Sling Surgery

Authors

  • Ewa Rechberger Medical University of Lublin
  • Tomasz Rechberger Medical University of Lublin
  • Sara Wawrysiuk Medical University of Lublin
  • Pawel Miotla Medical University of Lublin
  • Beata Kulik-Rechberger Medical University of Lublin
  • Andrzej Kuszka Hospital of Preetz
  • Andrzej Wróbel Medical University of Lublin

Keywords:

urinary tract infection, prophylaxis, midurethral sling, ciprofloxacin, phytodrug

Abstract

Urinary tract infections (UTIs) are one of the most common reasons for antibiotic prescriptions among women worldwide. UTIs are also associated with intra- and postoperative catheterization, which is an essential component of many gynecological surgical procedures, including midurethral sling (MUS) placement.

The aim of this study was to compare the incidence of UTI subsequent to a MUS procedure.

The study involved 562 female patients who underwent MUS procedures due to stress urinary incontinence (SUI). Patients were assigned in a 1:1 ratio to two study groups: patients receiving 500 mg of ciprofloxacin three times a day for 3 consecutive days after surgery or patients receiving 5 mL of Canephron taken orally three times a day for 3 weeks.

After analyzing the collected data, it was found that in the group of patients receiving ciprofloxacin, 29 women (10.98 %) had a UTI, whereas in the group of patients receiving Canephron, 36 women (13.64 %) had a UTI within 6 months after the patient’s MUS procedure. No statistically significant difference between the two groups was noted. Postoperative prophylaxis with a phytodrug can be perceived as an attractive option in the reduction of antibiotic consumption among female patients after a MUS procedure.

Author Biographies

Ewa Rechberger, Medical University of Lublin

Ewa Rechberger,

2nd Department of Gynecology, Medical Faculty

Tomasz Rechberger, Medical University of Lublin

Tomasz Rechberger,

2nd Department of Gynecology, Medical Faculty

Sara Wawrysiuk, Medical University of Lublin

Sara Wawrysiuk,

2nd Department of Gynecology, Medical Faculty

Pawel Miotla, Medical University of Lublin

Pawel Miotla,

2nd Department of Gynecology, Medical Faculty

Beata Kulik-Rechberger, Medical University of Lublin

Beata Kulik-Rechberger,

Department of Paediatric Propedeutics, Medical Faculty

Andrzej Kuszka, Hospital of Preetz

Andrzej Kuszka,

Department of Obstetrics and Gynecology, Medical Faculty

Andrzej Wróbel, Medical University of Lublin

Andrzej Wróbel,

2nd Department of Gynecology, Medical Faculty

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Published

2021-03-15

Issue

Section

Foreign Studies