Use of Acetylcysteine in the Treatment of Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Authors

  • І. І. Горпинченко State Institution «Institute of Urology of NAMS of Ukraine»
  • К. Р. Нуріманов State Institution «Institute of Urology of NAMS of Ukraine»
  • Т. В. Порошина State Institution «Institute of Urology of NAMS of Ukraine»
  • В. С. Савченко State Institution «Institute of Urology of NAMS of Ukraine»
  • Г. М. Драннік State Institution «Institute of Urology of NAMS of Ukraine»

DOI:

https://doi.org/10.30841/2307-5090.3.2020.215984

Keywords:

chronic prostatitis/chronic pelvic pain syndrome, acetylcysteine, quercetin, fertility

Abstract

Antioxidants are recommended for the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The efficacy and safety of quercetin in the treatment of patients with CP/CPPS have been studied most. To increase the effectiveness of treatment, we propose to use acetylcysteine, which, along with antioxidant properties, has secretolytic properties.

The objective: to provide a comparative assessment of the efficacy and safety of quercetin and acetylcysteine in the treatment of patients with CP/CPPS.

Materials and methods. The study involved 60 patients with CP/CPPS aged 18–45 years. Patients were randomized into two comparison groups. Patients in group 1 (n=30) were prescribed quercetin1 g per day for 1 month. Patients in group 2 (n=30) received acetylcyteine orally at a dose of 600 mg per day for 1 month. The condition of patients was assessed according to the NIH-CPSI scale, spermogram parameters and dynamics interlekin-10 (IL-10) and tumor necrosis factor α (TNF-α) in ejaculate. The efficiency criterion was considered to be a 25 % decrease in the NIH-CPSI.

Results. As a result of the treatment of patients with CP/CPPS with the use of antioxidants in both groups symptoms of the prostatitis were reduced: NIH-CPSI total (group 1 – 22,5±0,5 vs. 15,0±0,8; group 2 – 22,7±0,5 vs. 15,1±1,1); pain (group 1 – 11,5±0,3 vs. 7,1±0,4; group 2 – 10,0±0,5 vs. 6,6±0,6); urinary symptoms (group 1 – 3,4±0,3 vs. 2,1±0,2; group 2 – 4,8±0,4 vs. 2,2±0,4), quality of life (group 1 – 7,7±0,4 vs. 5,8±0,3; group 2 – 7,8±0,3 vs. 6,3±0,4). The fertility was improved significantly (p<0,05): increased sperm concentration, progressive sperm motility, decreased number of pathological sperm, leukocyte TNF-α concentration and increased IL-10 concentration in ejaculate. In group 2 only ejaculate viscosity decreased significantly (p<0,05), improved sperm motility, decreased white blood cell count, decreased TNF-α concentration in ejaculate were significantly greater than in group 1. The clinical efficacy of acetylcysteine and quercetin in the treatment of patients with CP/CPPS was 63,3 % and 60,0 % respectively (subject to the efficacy criterion of reducing the NIH-CPSI score by 25 %).

Conclusion. The use of acetylcysteine can be useful for patients with CP/CPPS.

Author Biographies

І. І. Горпинченко, State Institution «Institute of Urology of NAMS of Ukraine»

Ihor I. Gorpynchenko,

Head of Department of Sexopathology and Andrology

К. Р. Нуріманов, State Institution «Institute of Urology of NAMS of Ukraine»

Kamil R. Nurimanov,

Department of Sexopathology and Andrology

Т. В. Порошина, State Institution «Institute of Urology of NAMS of Ukraine»

Tetiana V. Poroshina,

Laboratory of Immunology

В. С. Савченко, State Institution «Institute of Urology of NAMS of Ukraine»

Viktoriia S. Savchenko,

Laboratory of Immunology

Г. М. Драннік, State Institution «Institute of Urology of NAMS of Ukraine»

Heorhii M. Drannik,

Head of Laboratory of Immunology

References

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Published

2020-09-30

Issue

Section

Sexology and andrology