DOI: https://doi.org/10.30841/2307-5090.3.2020.215909

Opportunities of Chronic Prostatitis Therapy with Flammulina velutipes

І. І. Горпинченко, В. В. Спиридоненко

Abstract


The relevance of the prevalence of chronic inflammatory diseases of the male genital area is currently quite high. Considering the inflammatory process as a promoter of the development of benign and malignant processes in the tissues of the prostate gland and seminal vesicles, modern pharmacology provides for the effect on pro-inflammatory factors, highlighting immune responses in cellular and humoral immunity, as one of the foundations for controlling inflammatory processes.

The use of Flammulina velutipes lyophilized biomass powder-in the above context has significant prospects for both therapeutic and prophylactic purposes, with minimal risks of developing adverse events and excellent compliance. The combination of the obtained pharmacological effects when using the lyophilized biomass powder of Flammulina velutipes indicates the possibility of obtaining a clinical effect in persons with inflammatory diseases of the prostate gland and seminal vesicles. Flammulina velutipes extract can be used both in combination and in monotherapy of inflammatory diseases of the prostate gland and seminal vesicles, given a fairly complete theoretical justification of their pharmacological effectiveness.

On the domestic pharmaceutical market there is a medical product Flamulin forte, the main composite of which is F. velutipes lyophilisate, which makes it possible to take advantage of its effects in the treatment of some urological and andrological nosologies. Flamulin forte, like the abovedescribed products from the extract of the fungus flamullin, can be used as an immunotropic and anti-inflammatory agent, the action of which is aimed at reducing the inflammatory response and optimizing some of the immune response in the body of a patient with chronic inflammatory diseases of the prostate vesicular complex.

Keywords


winter mushroom extract; flammulin mushroom; Flamulin forte; chronic prostatitis; inflammation

References


Горпинченко И.И. Гурженко Ю.Н., Спиридоненко В.В. (2015) Теоретичне обґрунтування ефективности фітотерапії у чоловіків із запальними захворюваннями передміхурової залози // Здоровье мужчины. – № 4 (55). – С. 45–49.

Горпинченко И.И., Гурженко Ю.Н., Спиридоненко В.В. (2016) Комбинированная фитотерапия при хронических воспалительных заболеваниях предстательной железы и их осложнения у больных сахарным диабетом // Здоровье мужчины. – № 2 (57). – C. 51–56.

Горпинченко І.І., Гурженко Ю.М., Спиридоненко В.В. (2014) Сучасні дані про вплив хронічного запалення в патогенезі ДГПЗ і рак простати // Здоровье мужчины. – № 4. – С. 91–94.

Djavan B. (2003) Lower urinary tract symptoms benign prostatic hyperplasia: fast control of the patient’s quality of life / /Urology.;62(3 Suppl 1): P. 6–14.

Martinon F., Petrilli V., Mayor A., Tardivel A., Tschopp J. (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome // Nature. V. 440. – P. 237–241.

De Marzo A.M., Platz E.A., Sutcliffe S. et al. (2007) Inflammation in prostate carcinogenesis // Nat Rev.V.7. – P. 256–269.

Drachenberg C.B., Papadimitriou J.C. (1996) Prostatic corpora amylacea and crystalloids: similarities and differences on ultrastructural and histochemical studies // J Submicroscop Cytol Pathol.V.28. – P. 141–150.

Karakiewicz P.I., Benayoun S., Begin L.R. et al. (2007) Chronic inflammation is negatively associated with prostate cancer and high grade prostatic intraepithelial neoplasia on needle biopsy // Int J Clin Pract. V.71. – P. 425–430.

Elkahwaji J.E., Zhong W., Bushman W. (2007) Chronic bacterial infection and inflammation incite reactive hyperplasia in a mouse model of chronic prostatitis // Prostate. V. 67. – P. 14–21.

Naber K., Weidner W. (2000) Chronic prostatitis: an infectious disease? // J Antimicrob. Chemother. V. 46. – P. 157–161.

Zhou T, Yang Y, Zhang H et al. (2014) Serenoa Repens Induces Growth Arrest, Apoptosis and Inactivation of STAT3 Signaling in Human Glioma Cells // Technol Cancer Res Treat. Jun V. 16. – P. 12–16.

Попович В.П., Козіко Н.О., Буткевич Т.А. (2015) Перспективи використання лікарського гриба Flammulina velutipes у медичній та фармацевтичній практиці // Фарм. журнал. – № 1. – С. 70–75.

Borhani A., Badalyan S. M., Garibyan N. et al. (2011) Flammulina Velutipes (Curt.: Fr.) Singer: An Edible Mushroom in Northern Forest of Iran and its Antagonistic Activity Against Selected Plant Pathogenic Fungi. V. 3, N 2. – Р. 162–167.

Hassan F.R.H., Ghada M., El-Kady A.T.M. (2012) Mycelial Biomass Production of Enoke Mushroom (Flammulina velutipes) by Submerged Culture // Australian J. Basic and Applied Sci. N 6 (7). – Р. 603–610.

Kim J.M., Ra K.S., Noh D.O. et al. (2002) Optimization of submerged culture conditions for the production of angiotensin converting enzyme inhibitor from Flammulina velutipes // J. Industr. Microbiol. Biotechnol. N 29 (5). – P. 292–295.

Leung M.Y.K., Fung K.P., Choy Y.M. (1997) The isolation and characterization of an immunomodulatory and antitumor Polysaccharide preparation from Flammulina velutipes // Immunopharmacol. N 35. – Р. 255–263.

Ko W.C., Liu W.C., Tsang Y.T., Hsieh C.W. (2007) Kinetics of winter mushrooms (Flammulina velutipes) microstructure and quality changes during thermal processing J. of Food Engineering, 81 (3), 587–598.

Maity K.K., Patra S., Dey B. et al. (2011) A heteropolysaccharide from aqueous extract of an edible mushroom, Pleurotus ostreatus cultivar: structural and biological studies - Carbohydr. Res., Feb 1, 346(2), 366–372.

Lin S.Y., Chen Y.K., Yu H.T., Barseghyan G.S., Asatiani M.D.,Wasser S.P., Mau J.L. (2013) Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms – Int. J. Med. Mushrooms, 15(3), 315–323.

Cohen N., Cohen J., Asatiani M.D. et al. (2014) Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms – Int. J. Med. Mushrooms, 16(3), 273–291.

Günç Ergönül P., Akata I., Kalyoncu F., Ergönül B. (2013) Fatty acid compositions of six wild edible mushroom species – Scientific World Journal, Jun 6, 2013, 163964.

Cai H., Liu X., Chen Z., Liao S., Zou Y. (2013) Isolation, purification and identification of nine chemical compounds from Flammulina velutipes fruiting bodies – Food Chem. Dec 1, 141(3), 2873–2879.

Kang J., Chen R.Y. (2005) [Studies on chemical constituents in the mycelia from fermented culture of Flammulina velutipes] – Zhongguo Zhong Yao Za Zhi., Feb., 30(3), 193–195.

Kang J., Chen R.Y. (2003) [Studies on chemical constituents of the mycelia from fermented culture of Flammulina velutipes] – Zhongguo Zhong Yao Za Zhi., Nov., 28(11), 1038–1040.

Ishikawa N.K., Fukushi Y., Yamaji K., Tahara S., Takahashi K. (2001) Antimicrobial cuparene-type sesquiterpenes, enokipodins C and D, from a mycelial culture of Flammulina velutipes – J. Nat. Prod., Jul., 64(7), 932–934.

Ishikawa N.K., Miura K., Tahara S. et al. (2005) Production of enokipodins A, B, C, and D: a new group of antimicrobial metabolites from mycelial culture of Flammulina velutipes // Mycoscience. 46: 1; P. 39–45.

Chou W.T., Sheih I.C., Fang T.J. (2013) The applications of polysaccharides from various mushroom wastes as prebiotics in different systems - J. Food Sci., Jul., 78(7), 1041–1048.

Mitchell L.A., Hansen R.J., Beaupre A.J., Gustafson D.L., Dow S.W. (2013) Optimized dosing of a CCR2 antagonist for amplification of vaccine immunity. International Immunopharmacology, 15(2). 357–363.

Yan Zheng-Fei, Liu Nai-Xu, Mao Xin-Xin, Li Yu, Li Chang-Tian (2014) Activation Effects of Polysaccharides of Flammulina velutipes Mycorrhizae on the T Lymphocyte Immune Function J. Of Immunol. Research. Article ID 285421. https://doi.org/10.1155/2014/285421.

Hu Q., Yu J., Yang W., Kimatu B.M., Fang Y., Ma N., Pei F. (2016) Identification of flavonoids from Flammulina velutipes and its neuroprotective effect on pheochromocytoma-12 cells // Food Chem. Aug 1, 204, 274–282.

Fukushima M., Ohashi T., Fujiwara Y., Sonoyama K., Nakano M. (2001) Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats – Exp. Biol. Med. (Maywood), Sep., 226(8), 758–765.

Yan Z.F., Liu N.X., Mao X.X., Li Y., Li C.T. (2014) Activation effects of polysaccharides of Flammulina velutipes mycorrhizae on the T-lymphocyte immune function – J. Immunol. Res., 2014, 285421.

Rahman M.A., Abdullah N., Aminudin N. (2015) Antioxidative Effects and Inhibition of Human Low Density Lipoprotein Oxidation In Vitro of Polyphenolic Compounds in Flammulina velutipes (Golden Needle Mushroom) // Oxid. Med. Cell. Longev., 403023.

Chang Y.C., Chow Y.H., Sun H.L., Liu Y.F., Lee Y.T., Lue K.H., Ko J.L. (2014) Alleviation of respiratory syncytial virus replication and inflammation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes // Antiviral. Res., Oct., 110, 124–131.

Krupodorova T., Rybalko S., Barshteyn V. (2014) Antiviral activity of Basidiomycete mycelia against influenza type A (serotype H1N1) and herpes simplex virus type 2 in cell culture – Virol. Sin., Oct., 29(5), 284–290.

Shang X., Tan Q., Liu R., Yu K., Li P., Zhao G.P. (2013) In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom, Hericium erinaceus (higher Basidiomycetes) // Int. J. Med. Mushrooms, 15(2), 165–174.

Hsieh K.Y., Hsu C.I., Lin J.Y., Tsai C.C., Lin R.H. (2003) Oral administration of an edible-mushroom-derived protein inhibits the development of food-allergic reactions in mice – Clin. Exp. Allergy. Nov., 33(11), 1595–1602.

Monro J.A. (2003) Treatment of cancer with mushroom products – Arch. Environ. Health. Aug., 58(8), 533–537.

Kashinath K., Jadhav P.D., Reddy D.S. (2014) Total synthesis of an anticancer norsesquiterpene alkaloid isolated from the fungus Flammulina velutipes // Org. Biomol. Chem., Jun 28, 12(24), 4098–4103.

Jiang S.M., Xiao Z.M., Xu Z.H. (1999) Inhibitory activity of polysaccharide extracts from three kinds of edible fungi on proliferation of human hepatoma SMMC-7721 cell and mouse implanted S180 tumor // World J. Gastroenterol., Oct., 5(5), 404–407.

Zhang Z., Lv G., He W., Shi L., Pan H., Fan L. (2013) Effects of extraction methods on the antioxidant activities of polysaccharides obtained from Flammulina velutipes // Carbohydr. Polym. Nov 6, 98(2), 1524–1531.

Wu M., Luo X., Xu X. et al. (2014) Antioxidant and immunomodulatory activities of a olysaccharide from Flammulina velutipes // J. Tradit. Chin. Med., Dec., 34(6),733–740.

Xia Z. (2015) Preparation of the oligosaccharides derived from Flammulina velutipes and their antioxidant activities // Carbohydr. Polym. Mar 15, 118, 41–43.

Yin H., Wang Y., Wang Y., Chen T., Tang H., Wang M. (2010) Purification, characterization and immuno-modulating properties of polysaccharides isolated from Flammulina velutipes mycelium // Am. J. Chin. Med., 38(1), 191–204.

Yan Z.F., Liu N.X., Mao X.X., Li Y., Li C.T. (2014) Activation effects of polysaccharides of Flammulina velutipes mycorrhizae on the Tlymphocyte immune function // J. Immunol. Res. 2014, 285. 421.

Chang H.L., Lei L.S., Yu C.L. et al. (2009) Effect of Flammulina velutipes polysaccharides on production of cytokines by murine immunocytes and serum levels of cytokines in tumor bearing mice // Zhong Yao Cai. Apr., 32(4), 561–563.

Ikekawa T., Ikeda Y., Yoshioka Y., Nakanishi K., Yokoyama E., Yamazaki E. (1982) Studies on antitumor polysaccharides of Flammulina velutipes (Curt. ex Fr.) Sing. II. The structure of EA3 and further purification of EA5 // J. Pharmacobiodyn., Aug., 5(8), 576–581.

Ikekawa T., Maruyama H., Miyano T. et al. (1985) Proflamin, a new antitumor agent: preparation, physicochemical properties and antitumor activity // Jpn. J. Cancer. Res. Feb., 76(2), 142–148.

Otagiri K., Ohkuma T., Ikekawa T., Tanaka S. (1983) Intensification of antitumor-immunity by protein-bound polysaccharide, EA6, derived from Flammulina velutipes (Curt. ex Fr.) Sing. combined with murine leukemia L1210 vaccine in animal experiments // J.Pharmacobiodyn. 6(2), 96–104.

Ou H.T., Shieh C.J., Chen J.Y., Chang H.M. (2005) The antiproliferative and differentiating effects of human leukemic U937 cells are mediated by cytokines from activated mononuclear cells by dietary mushrooms // J.Agric. Food. Chem. Jan 26, 53(2), 300–305.

Gu Y.H., Leonard J. (2006) In vitro effects on proliferation, apoptosis and colony inhibition in ER-dependent and ER-independent human breast cancer cells by selected mushroom species –Oncol. Rep. Feb.,15(2), 417–423.

Karaman M., Jovin E., Malbasa R., Matavuly M., Popović M. (2010) Medicinal and edible lignicolous fungi as natural sources of antioxidative and antibacterial agents – Phytother. Res. Oct., 24(10), 1473–1481.

Bao H.N., Ochiai Y., Ohshima T. (2010) Antioxidative activities of hydrophilic extracts prepared from the fruiting body and spent culture medium of Flammulina velutipes // Bioresour. Technol. Aug., 101(15), 6248–6255.

Lee J.S., Oka K., Watanabe O., Hara H., Ishizuka S. (2011) Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents // Food. Chem. Jun 15,126(4), 1521–1526.

Yi C., Sun C., Tong S. et al. (2013) Cytotoxic effect of novel Flammulina velutipes sterols and its oral bioavailability via mixed micellar nanoformulation – Int. J.Pharm. May 1, 448(1), 44–50.

Chen P., Yong Y., Gu Y. et al. (2015) Comparison of antioxidant and antiproliferation activities of polysaccharides from eight species of medicinal mushrooms – Int. J. Med. Mushrooms, 17(3), 287–295.

Paaventhan P., Joseph J.S., Seow S.V. et al. А structure of fve, a member of the new fungal immunomodulatory protein family // J. Mol. Biol. – 2003. – V. 332, N 2. – Р. 461–470.

Chang H.H., Hsieh K.Y., Yeh C.H. et al. (2010) Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces antitumor activity against murine hepatocellular carcinoma // Inter. Immunopharmacol. N 10 (2). – P. 239–246.

Wang P.H., Hsu C.I., Tang S.C. et al. (2004) Fungal immunomodulatory protein from Flammulina velutipes induces interferon-gamma production through p38 mitogen-activated protein kinase signaling pathway - J. Agric. Food Chem. May 5, 52(9), 2721–2725.

Ko J.L., Hsu C.I., Lin R.H., Kao C.L., Lin J.Y. (1995) A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence – Eur. J.Biochem. Mar 1, 228(2), 244–249.

Ngai T.B., Ngai P.H., Xia L. (2006) An agglutinin with mitogenic and antiproliferative activities from the mushroom Flammulina velutipes – Mycologia, Mar-Apr., 98(2), 167–171.

Lee Y.T., Lee S.S., Sun H.L. et al. (2013) Effect of the fungal immunomodulatory protein FIP-fve on airway inflammation and cytokine production in mouse asthma model – Cytokine. Jan., 61(1), 237–244.

Chang Y.C., Hsiao Y.M., Wu M.F. et al. (2013) Interruption of lung cancer cell migration and proliferation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes – J. Agric. Food Chem. Dec 11, 61(49), 12044–12052.

Kim M.Y., Seguin P., Ahn J.K. et al. (2008) Phenolic compound concentration and antioxidant activities of edible and medical mushrooms from Korea // J. Agricultural and Food Chem. N 5. – Р. 7265–7270.

Jang M.S., Eun J.B., Ushio H. et al. (2004) Antioxidative properties of mushroom Flammulina velutipes crude extract on the oxidation of col liver oil in emulsion // Food Sci. Biotechnol. N 13. – P. 215–218.

Jang M.S., Park H.Y., Ushio H. et al. (2009) Antioxidative effects of mushroom Flammulina velutipes extract on polyun-saturated oils in oil-in-water emulsion // Ibid. V. 18, N 3. – P. 604–609.

He J.Z., Ru Q.M., Dong D.D. et al. (2012) Chemical characteristics and antioxidant properties of crude water soluble polysaccharides from four common edible mushrooms // Molecules. N 17. – P. 4373–4387.

Soobrattee M.A., Neergheen V.S., Luximon-Ramma A., Aruoma O.I., Bahorun T. (2005) Phenolics as potential antioxidant therapeutic agents: Mechanism and actions. Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis, 579; 1-2, 200–213.

Williams R.J., Spencer J.P.E., Rice-Evans C. (2004) Flavonoids: antioxidants or signalling molecules? Free Radical Biology and Medicine. 36 (7), 838–849.

Rahman I., Biswas S.K., Kirkham P.A. (2006) Regulation of inflammation and redox signaling by dietary polyphenols // Biochemical Pharmacology, 72 (11), 1439–1452.

Hollman P.C.H., Cassidy A., Comte B. et al. (2011) The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established // The J. of Nutrition.,141 (5). 989–1009.

Holst B., Williamson G. (2008) Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants // Current Opinion in Biotechnology. 19 (2). 73–82.

Mohammad A.R., Noorlidah A., Norhaniza A. (2015) Antioxidative Effects and Inhibition of Human Low Density Lipoprotein Oxidation In Vitro of Polyphenolic Compounds in Flammulina velutipes (Golden Needle Mushroom) // Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity. Article ID 403023, 10 pages.

Ukaegbu C.I., Shah S.R., Hazrulrizawati A.H., Alara O.R. (2018) Acetone extract of Flammulina velutipes caps: A promising source of antioxidant and anticancer agents // Beni-Suef University Journal of Basic and Applied Sciences 7 675–682.

Краснопольская Л.М., Шуктуева М.И., Автономова А.В. и соавт. (2016) Противоопухолевые и антиоксидантные свойства водорастворимых полисахаридов из мицелия базидиального гриба Flammulina velutipes // Антибиотики и химиотерапия, 61; 11–12. – С. 16–20.

Ying Ding, See Voon Seow, Chiung Hui Huang et al. (2009) Coadministration of the fungal immunomodulatory protein FIP-Fve and a tumour-associated antigen enhanced antitumour immunity // Immunology, 128, 881– 894.

Fangfang Yuan, Zheng Gao, Wenbo Liu, et al. (2019) Characterization, Antioxidant, Anti-Aging and Organ Protective Effects of Sulfated Polysaccharides from Flammulina velutipes // Molecules, 24, 3517; doi:10.3390/molecules24193517.

Kang YJ, Wingerd BA, Arakawa T, Smith W. (2006) Cyclooxygenase-2 gene transcription in a macrophage model of inflammation. J Immunol., 177:8111–8122.

Kang BY, Chung SW, Im SY, Hwang SY, Kim TS: (1999) Chloromethyl ketones inhibit interleukin-12 production in mouse macrophages stimulated with lipopolysaccharide. Immunol Lett., 70:135–138.

Kaplanski G, Marin V, Farnarier C. (2003) IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol., 24:25–29.

Lawrence T, Willoughby DA, Gilroy DW. (2002) Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nature Rev Immunol., 2:787–795.

Takeda K, Akira S. (2000) Toll-like receptors in innate immunity. Int Immunol 2005, 17:1-14. Aderem A, Ulevitch RJ: Toll-like receptors in the induction of the innate immune response. Nature, 406:82–787.

Jedinak A., Dudhgaonkar S., Wu Q., Simon J., Sliva D. (2011) Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-B and AP-1 signaling // Nutrition Journal, 10:52.

Лукьянчук В.Д., Мищенко Е.М., Бабенко М.Н. (2011) Бета-глюканы как основа создания средств иммуномодулирующего действия // Укр. мед. часопис, 5 (85). С. 92–93.

Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ. Gershwin ME (2008) The immunobiology of mushrooms. Exp Biol Med (Maywood), 233:259–276.




Copyright (c) 2020 І. І. Горпинченко, В. В. Спиридоненко

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

ISSN 2412-5547 (Online), ISSN 2307-5090 (Print)