DOI: https://doi.org/10.30841/2307-5090.3.2019.185357

Biological Therapy of Patients with Hypersexuality

Г. С. Кочарян

Abstract


The article notes that hypersexuality can be eliminated with successful therapy of the pathology that led to its appearance, as well as the need to treat concomitant pathological mental conditions that can directly or indirectly affect problematic sexual behavior. Medications of various groups that are used to eliminate hypersexuality are presented: selective serotonin reuptake inhibitors, tricyclic antidepressants, opiate receptor blockers, antiepileptic drugs, tranquilizers, antipsychotics, cholinesterase inhibitor rivastigmine, estrogens, analogues of gonadotropin releasing hormone, normotonic lithium carbonate and etc., as well as some recommendations for the management of patients with Parkinson’s disease in whom hypersexuality resulted from the use of dopaminergic drugs. Cases of the use of electroconvulsive therapy and deep brain stimulation in this pathology are submitted.

Keywords


hypersexuality; biological therapy

References


Никитина А.В., Федорова Н.В. Импульсивно-компульсивный синдром при болезни Паркинсона // Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (Выпуск 2. Неврология и психиатрия пожилого возраста). – 2013. – 113 (7). – P. 32–38.

Нормотимики. – URL: https://ru.wikipedia.org/wiki/Нормотимики (дата обращения: 23.08.2019).

Прогестогены. – URL: https://ru.wikipedia.org/wiki/Прогестогены (дата обращения: 19.08.2019).

Alkhalil C., Tanvir F., Alkhalil B., Lowenthal D.T. Treatment of sexual disinhibition in dementia: case reports and review of the literature // Am J Ther. – 2004. – 11 (3). – P. 231–235.

Asiff M., Sidi H., Masiran R., Kumar J., Das S., Hatta N.H., Alfonso C. Hypersexuality As a Neuropsychiatric Disorder: The Neurobiology and Treatment Options // Curr Drug Targets. – 2018. – 19 (12). – P. 1391–1401. DOI: 10.2174/1389450118666170321144931.

Black D.W., Kehrberg L.L., Flumerfelt D.L., Schlosser S.S. Haracteristics of 36 subjects reporting compulsive sexual behavior // American Journal of Psychiatry. – 1997. – 154 (2). – P. 243–249. DOI:10.1176/ajp.154.2.243

Bostwick J.M., Bucci J.A. Internet sex addiction treated with naltrexone // Mayo Clin Proc. – 2008. – 83 (2). – P. 226–230.

Briken P., Habermann N., Berner W., Hill A. Diagnosis and treatment of sexual addiction: A survey among German sex therapists // Sex Addict Compulsivity. – 2007. – 14. – P. 131–143.

Briken P., Hill A., Berner W. Pharmacotherapy of paraphilias with long-acting agonists of luteinizing hormone-releasing hormone: a systematic review // J Clin Psychiatry. – 2003. – 64 (8). – P. 890–897.

Britton K.R. Medroxyprogesterone in the treatment of aggressive hypersexual behavior in traumatic brain injury // Brain Inj. – 1998. – 12 (8). – P. 703–707.

Canevelli M., Talarico G., Tosto G., Troili F., Lenzi G.L., Bruno G. Rivastigmine in the Treatment of Hypersexuality in Alzheimer Disease // Alzheimer Dis Assoc Disord. – 2013. – 27 (3). – P. 287–288. DOI: 10.1097/WAD.0b013e31825c85ae.

Cheon E., Koo B.H., Seo S.S., Lee J.Y. Two Cases of Hypersexuality Probably Associated with Aripiprazole // Psychiatry Investig. – 2013. – 10 (2). – P. 200–202. DOI: 10.4306/pi.2013.10.2.200.

Chughtai B., Sciullo D., Khan S.A., Rehman H., Mohan E., Rehman J. Etiology, diagnosis & management of hypersexuality: a review // The Internet Journal of Urology. – 2009. – 6 (2). DOI: 10.5580/1231

Coleman Eli, Dickenson Janna A., Girard Abby, Nicole Rider G., Candelario-Perez Leonardo E., Becker-Warner Rachel, Kovic Alexander G., Munns Rosemary. An Integrative Biopsychosocial and Sex Positive Model of Understanding and Treatment of Impulsive/Compulsive Sexual Behavior // Sexual Addiction & Compulsivity. – 2018. – 25 (2–3). – P. 125–152. DOI: 10.1080/10720162.2018.1515050

Djamshidan A., Сardoso F., Grosset D., Bowden-Jones H., Lees A.J. Pathological gambling in Parkinson’s disease – a review of a literature // Mov Disord. – 2011. – 26 (11). – P. 1976–1984.

Ferrara J.M., Stacy M. Impulsive controle disorders and Parkinson’s disease // CNS Spectr. – 2008. – 13 (8). – P. 690–698.

Hanada H., Akiyoshi J., Kanehisa M., Ishitobi Y., Tsuru J., Tanaka Y., Shimomura Т., Kawano Y. Hippocampal Agenesis in an Individual who Engaged in Violent Criminal Behaviors After Discontinuing Carbamazepine and Paroxetine Treatment // J Forensic Sci. – 2013. – 58 (1). – P. 255–258. DOI: 10.1111/j.1556-4029.2012.02248.x.

Hardy J., Cowburn R., Barton A., Reynolds G., Dodd P., Wester P., O’Carroll A.M., Lofdahl E., Winblad B.A disorder of cortical GABAergic innervation in Alzheimer’s disease // Neurosci Lett. – 1987. – 73 (2). – P. 192–196.

Haussermann P., Goecker D., Beier K., Schroeder S. Low-dose cyproterone acetate treatment of sexual acting out in men with dementia // International Psychogeriatrics. – 2003. – 15 (2). – P. 181–186.

Herrmann N., Lanctôt K., Myszak M. Effectiveness of gabapentin for the treatment of behavioral disorders in dementia // J Clin Psychopharmacol. – 2000. – 20 (1). – P. 90–93.

Jefferson J.W. Lithium encyclopedia for clinical practice. 2nd ed. – Washington, DC: American Psychiatric Press, 1987.

Kafka M.P., Prentky R.A. Compulsive sexual behavior characteristics // American Journal of Psychiatry. – 1997. – 154 (11). – P. 1632. DOI:10.1176/ajp.154.11.1632

Kaplan M.S., Krueger R.B. Diagnosis, assessment, and treatment of hypersexuality // J Sex Res. – 2010. – 47 (2). – P. 181–198.

Kraus Shane W., Voon Valerie, Potenza Marc N. Should compulsive sexual behavior be considered an addiction? // Addiction. – 2016. – 111 (12). – P. 2097–2106.

Kyomen H.H., Nobel K.W., Wei J.Y. The use of estrogen to decrease aggressive physical behavior in elderly men with dementia // J Am Geriatr Soc. – 1991. – 39 (11). – P. 1110–1112.

Lardinois C.K., Mazzaferri E.L. Cimetidine blocks testosterone synthesis // Arch Intern Med. – 1985. – 145 (5). – P. 920–922.

Lesser J.M., Hughes S.V., Jemelka J.R., Griffith J. Sexually inappropriate behaviors. Assessment necessitates careful medical and psychological evaluation and sensitivity // Geriatrics. – 2005. – 60 (1). – P. 34, 36–37.

Levitsky A.M., Owens N.J. Pharmacologic treatment of hypersexuality and paraphilias in nursing home residents // J Am Geriatr Soc. – 1999. – 47 (2). – P. 231–234.

Lothstein L.M., Fogg-Waberski J., Reynolds P. Risk management and treatment of sexual disinhibition in geriatric patients // Conn Med. – 1997. – 61 (9). – P. 609–618.

Miller L.J. Gabapentin for treatment of behavioral and psychological symptoms of dementia // Annals of Pharmacotherapy. – 2001. – 35. – P. 427–431.

Ott B.R. Leuprolide treatment of sexual aggression in a patient with dementia and the Klüver-Bucy syndrome // Clin Neuropharmacol. – 1995. – 18 (5). – P. 443–447.

Raja M., Bentivoglio A.R. Impulsive and compulsive behaviors during dopamine replacement treatment in Parkinson’s Disease and other disorders // Curr Drug Saf. – 2012. – 7 (1). – P. 63–75.

Rasroussen S.A. Lithium and tryptophan augmentation in clomipramine-resistant obsessive-compulsive disorder // American Journal of Psychiatry. – 1984. – l4l (10). – P. 1283–1285.

Raymond N.C., Coleman E., Miner M. Psychiatric comorbidity and compulsive/impulsive traits in compulsive sexual behavior // Comprehensive Psychiatry. 2003. – 44 (5). – P. 370–380. DOI:10.1016/S0010-440X(03)00110-X)

Raymond N.C., Grant J.E., Coleman E. Augmentation with naltrexone to treat compulsive sexual behavior: a case series // Ann Clin Psychiatry – 2010. – 22 (1). – P. 56–62.

Regan W.M., Gordon S.M. Gabapentin for behavioral agitation in Alzheimer’s disease // J Clin Psychopharmacol. – 1997. – 17 (1). – P. 59–60.

Rich S.S., Ovsiew F. Leuprolide acetate for exhibitionism in Huntington’s disease // Mov Disord. – 1994. – 9 (3). – P. 353–357.

Roane D.M., Feinberg T.E., Meckler L., Miner C.R., Scicutella A., Rosenthal R.N. Treatment of dementia-associated agitation with gabapentin // J Neuropsychiatry Clin Neurosci. – 2000. – 12 (1). – P. 40–43.

Semanchuk M.R., Labiner D.M. Gabapentin and lamotrigine: prescribing guidelines for psychiatry // Journal of Practical Psychiatry and Behavioral Health. – 1997. – 3. – P. 334–342.

Series Hugh, Dégano Pilar. Hypersexuality in dementia // Advances in Psychiatric Treatment. – 2005. – 11 (6). – P. 424–431. https://doi.org/10.1192/apt.11.6.424

Sex Addiction Symptoms, Causes and Effects. – URL: https://www.psychguides.com/guides/sex-addiction-symptomscauses-and-effects/ (the date of the reference: 02.04.2019).

Siegel M., Milligan B., Robbins D., Prentice G. Electroconvulsive therapy in an adolescent with autism and bipolar I disorder // J ECT. – 2012. – 28 (4). – P. 252–255. DOI: 10.1097/YCT.0b013e31825cec86.

Volpe F.M., Tavares A. Cyproterone for hypersexuality in a psychotic patient with Wilson’s disease // Aust N Z J Psychiatry. – 2000. – 34 (5). – P. 878–879.

Wainberg M.L., Muench F., Morgenstern J., Hollander E., Irwin T.W., Parsons J.T., Allen A., O’Leary A. A doubleblind study of citalopram versus placebo in the treatment of compulsive sexual behaviors in gay and bisexual men // The Journal of clinical psychiatry. – 2006. – 67 (12). – P. 1968–1973.

Wiseman S.V., McAuley J.W., Freidenberg G.R., Freidenberg D.L. Hypersexuality in patients with dementia: possible response to cimetidine // Neurology. – 2000. – 54 (10). – P. 2024.


 

Cited-by:

1. Hypersexuality in a Woman: a Case from Clinical Practice
Г. С. Кочарян
Health of Man  Issue: 3  First page: 52  Year: 2020  
doi: 10.30841/2307-5090.3.2020.215972



Copyright (c) 2020 Г. С. Кочарян

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