Combination Therapy for Erectile Dysfunction


І. М. Антонян
Ф. Г. Мошель


The objective: to evaluate the efficacy and safety of using hormone replacement therapy with testosterone in combination with iFDE-5 (udenafil) in the treatment of erectile dysfunction (ED) in men with androgen deficiency associated with type 2 diabetes mellitus (DM).

Materials and methods. The study involved 20 patients with type 2 diabetes and signs of ED on the background of secondary hypogonadism. Before treatment, patients underwent a standard clinical examination in a urological hospital, after which they were equally divided into two groups using a «tossed coin». Patients of group I (n = 10) received testosterone HRT at a dose of 50 mg / day for 12 weeks, patients of group II (n=10) used testosterone hormone combined with udenafil (100–200 mg/day twice and more than once a week) also for 12 weeks.

Results. It was proved that after 12 weeks of therapy, the level of total testosterone in the combination therapy group increased from 6.6±1.3 to 17.1±4.2 nmol/ml, while in the monotherapy group the changes were less pronounced – from 5,6±1.2 to 13.3±2.3 nmol/ml. An important indicator for patients with type 2 diabetes – glucose level – also showed significant changes in the combination therapy group: from 10.2±2.7 to 6.9±1.6 mmol/l compared with the results of the monotherapy group: from 9,9±2.4 to 8.1±1.5 mmol/l.

Conclusion. Erectile dysfunction therapy in men with androgen deficiency in patients with type 2 diabetes with hormone replacement therapy with testosterone in combination with phosphodiesterase-5 inhibitor (udenafil) can be an effective alternative to traditional hormone replacement therapy, but further research is needed in this direction.


How to Cite
Антонян, І. М., & Мошель, Ф. Г. (2018). Combination Therapy for Erectile Dysfunction. Health of Man, (4), 15–19.
Topical issues
Author Biographies

І. М. Антонян, Kharkiv Medical Academy of Postgraduate Education

Ihor M. Antonyan,

Head of Department of General, Pediatric and Oncology Urology

Ф. Г. Мошель, Kharkiv Medical Academy of Postgraduate Education

Fedir H. Moshel,

Department of General, Pediatric and Oncology Urology


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