The use of herbal drug Canephron® N in ambulatory meta-prevention of uratolysis
The objective: was to assess the efficacy and safety of Canephron® N in the metaphysics of urate urolithiasis.
Materials and methods. In this single-center, prospective, openlabel, non-randomized, controlled, parallel study, 60 patients with urethra-urethritis urolithiasis (39 men and 21 women) who underwent disintegration/dislocation of concrements, were divided into two groups. In the main group, patients complied with the general preventive measures for liquids and nutrition recommended by the EAU, and Canephron® N was used in standard dosages for 6 months.
Results. The daily diuresis, uric acid levels of blood and urine, the level of magnesium in urine, and the rate of recurrence of urolithiasis in both groups were evaluated.Conclusion. It was found that the use of Canephron® N with the purpose of secondary prevention of uratogenic urolithiasis causes a significant decrease in the factors of urine lithogenicity: a decrease in the concentration of uric acid in urine, an increase in daily diuresis and a change in urine pH to physiologically optimal amounts, contributes to a significant increase in the concentration of Mg + ions in urine, reduces the rate of relapse of urethane lithiasis in stone formation compared with standard secondary prevention of IBD in 3.8 times.
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