Use of Canephron® N in treatment of acute uncomplicated cystitis in women

Р. Э. Амдий, С. Х. Аль-Шукрі, И. В. Кузьмін, М. В. Сорокін, Є. О. Чаплицький, М. В. Скворцов, О. С. Алексєєв, А. Ш. Окунчаєв, О. А. Турбін, Г. Р. Тимаєва, Д. В. Булаєв, Ю. С. Москальова


The objective: of study was to evaluate the efficacy and safety of Canephron® N with uncomplicated cystitis in women in clinical practice.
Patients and methods. In our work was attended by 22 women with a diagnosis of acute uncomplicated cystitis. The mean age was 29,0±1,8 years (from 19 to 51 years. The criteria of effectiveness were changes in symptoms and laboratory parameters according to the urinary tests at Canephron® N monotherapy.
Results. After treating by Canephron® N there were observed significant improvement in symptoms of acute cystitis. Before treatment the average symptom score was 8,05±0,7 points, on the 3rd day of treatment it significantly decreased to 5,1±1,0 points (p<0,05) on day 7 of treatment it was up to 2,9±1,0 points, in the phase of observation of 37 days after initiation of therapy by Canephron® N othe average score of symptoms was 0,1±0,3 points. Frequency leukocyturia on the 7 day of treatment according to a study by urine microscopy was 83,3%, and by the 37 th day after the start of Canephron® N (phase monitoring) significantly decreased to 37,5% (p<0,05). Canephron® N showed statistically significant antibacterial activity in acute cystitis. Prior to initiating therapy the growth of microorganisms at a titer of more than 100 000 units was detected in 72,7% of patients after 2 weeks of treatment (on day 37 of observation) – in 28,6% of patients (p<0,05).
Conclusions. Our results suggest that Canephron® N can be an effective and well-tolerated alternative treatment of uncomplicated infections of the lower urinary tract in women, allowing to reduce the use of antibiotics. Appointment of the drug as a monotherapy Canephron® N acute cystitis and duration of treatment requires further study and discussion.


treatment of acute cystitis; Canephron® N; uncomplicated infections of the lower urinary tract


Little P, Moore MV, Turner S, et al. Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial. BMJ. 2010;340:199-204. doi: 10.1136/bmj.c199.

Ivanov D, Abramov-Sommariva D, Moritz К, et al. An open label, non-controlled, multicentre, interventional trial to investigate the safety and efficacy of Canephron® N in the managementof uncomplicated urinary tract infections (uUTIs). Clinical Phytoscience. 2015;1(7):1-11. doi: 10.1186/s40816-015-0008-x.

Wagenlehner FM, Weidner W, Naber KG. An update on uncomplicated urinary tract infections in women. Current Opinion in Urology. 2009;19:368-374. doi: 10.1097/mou.0b013e32832ae18c.

Ferry SA, Holm SE, Stenlund H, et al. The natural course of uncomplicated lower urinary tract infection in women illustrated by a randomized placebo controlled study. Scand J Inf Dis. 2004;36:296-301. doi: 10.1080/00365540410019642.

Naber KG. Efficacy and safety of the phytotherapeutic drug Canephron® N in prevention and treatment of urogenital and gestational disease: review of clinical experience in eastern europe and central asia. Research and reports in Urology. 2013;5:39-46. doi: 10.2147/rru.s39288.

Copyright (c) 2020 Р. Э. Амдий, С. Х. Аль-Шукрі, И. В. Кузьмін, М. В. Сорокін, Є. О. Чаплицький, М. В. Скворцов, О. С. Алексєєв, А. Ш. Окунчаєв, О. А. Турбін, Г. Р. Тимаєва, Д. В. Булаєв, Ю. С. Москальова

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

ISSN 2412-5547 (Online), ISSN 2307-5090 (Print)