Use of Canephron® N in treatment of acute uncomplicated cystitis in women
Patients and methods. In our work was attended by 22 women with a diagnosis of acute uncomplicated cystitis. The mean age was 29,0±1,8 years (from 19 to 51 years. The criteria of effectiveness were changes in symptoms and laboratory parameters according to the urinary tests at Canephron® N monotherapy.
Results. After treating by Canephron® N there were observed significant improvement in symptoms of acute cystitis. Before treatment the average symptom score was 8,05±0,7 points, on the 3rd day of treatment it significantly decreased to 5,1±1,0 points (p<0,05) on day 7 of treatment it was up to 2,9±1,0 points, in the phase of observation of 37 days after initiation of therapy by Canephron® N othe average score of symptoms was 0,1±0,3 points. Frequency leukocyturia on the 7 day of treatment according to a study by urine microscopy was 83,3%, and by the 37 th day after the start of Canephron® N (phase monitoring) significantly decreased to 37,5% (p<0,05). Canephron® N showed statistically significant antibacterial activity in acute cystitis. Prior to initiating therapy the growth of microorganisms at a titer of more than 100 000 units was detected in 72,7% of patients after 2 weeks of treatment (on day 37 of observation) – in 28,6% of patients (p<0,05).
Conclusions. Our results suggest that Canephron® N can be an effective and well-tolerated alternative treatment of uncomplicated infections of the lower urinary tract in women, allowing to reduce the use of antibiotics. Appointment of the drug as a monotherapy Canephron® N acute cystitis and duration of treatment requires further study and discussion.
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Copyright (c) 2020 Р. Э. Амдий, С. Х. Аль-Шукрі, И. В. Кузьмін, М. В. Сорокін, Є. О. Чаплицький, М. В. Скворцов, О. С. Алексєєв, А. Ш. Окунчаєв, О. А. Турбін, Г. Р. Тимаєва, Д. В. Булаєв, Ю. С. Москальова
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