Salvage radical prostatectomy after distance radiation therapy: a systematic review of modern approaches

С. В. Головко, О. Ф. Савицький


Radical external radiation therapy (RERT) is the standard for the treatment of prostate cancer patients (PCa). Despite this, the incidence of intraprostatic recurrence after primary RERT is still significant, there is still no consensus on the best treatment for these patients after ineffective RERT. For such patients, local salvage therapy may be indicated, namely, radical prostatectomy, cryotherapy, or brachytherapy.
The objective: analysis of possible criteria for careful selection of relevant patients, assessment of cancer outcomes and complications of each method.
Patients and methods. A review of the literature was carried out to identify studies on local salvage therapy in patients who had an ineffectiveness of primary RERT in localized PCa.
Results. Most studies suggest that local salvage therapy after RERT can provide long-term local control in correctly selected patients, although there is toxicity of treatment.
Conclusion. The results of the study suggest that for localized prostate cancer after external radiation radiotherapy, the choice of the local treatment model should be applied on the basis of an individual approach to each patient. Further research is continuing that it provides the best oncological and comorbid results, in particular by improving the selection criteria and the integral determination of biochemical disorders for all salvage methods.


remote radiation therapy; relapse of prostate cancer; radiation therapy; salvage prostatectomy


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