Clinical significance of determining neovascularization in patients with germ cell tumor of testis


А. М. Романенко
Л. М. Захарцева
А. В. Сакало


Study of the angiogenesis during the growth of malignant tumor is a critical issue of modern oncology. These studies yielded drugs and combinations of medicines of anti VEGF therapy. One of main regulators of angiogenesis is vessel endothelial growth factor (VEGF). We performed quantitative analysis of  neoangiogenesis by examining vascular density (VD) in 51 patients with primary tumor of testis, and compared with clinical and morphological features of patients. We established probable correlation between VD level and stage, progression and prognosis of the disease (р=0.001, р=0.013 and р=0.003, respectively) and intensity of   expression of VEGF (р<0.0001). Neovasculatisation of nonsemi   nomatous tumors is higher than that of seminomatous ones  (р=0.019).


How to Cite
Романенко, А. М., Захарцева, Л. М., & Сакало, А. В. (2015). Clinical significance of determining neovascularization in patients with germ cell tumor of testis. Health of Man, (4(55), 134–137.
Author Biographies

А. М. Романенко, ГУ «Институт урологии НАМН Украины»

А.М. Romanenko

Л. М. Захарцева, Киевский городской клинический онкологический центр

L.M. Zakhartseva

А. В. Сакало, ГУ «Институт урологии НАМН Украины»

А.V. Sаkаlо


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