DOI: https://doi.org/10.30841/2307-5090.4(59).2016.104443

Research of the efficacy and safety of Epadol Neo in patients with excretory toxic infertility

Є. А. Литвинець, В. Є. Литвинець-Кондрат

Abstract


According to WHO, about 8–12% of couples suffer from infertility. Demographics of many countries show an increase in the proportion of contravention of fertility in men, reaching an average of 30% to 50% of the causes of infertile marriages and tends to increase recently.

The objective: of our study was to investigate the efficacy and safety of using the medications Epadol neo in the treatment of patients with excretory toxic infertility with chronic inflammatory diseases of the genitourinary system on background (chronic prostatouretritis, chronic prostatitis).

Patients and methods. We treated and observed 60 patients with excretory toxic infertility as astenozoosperm with chronic inflamma tory diseases of the genitourinary system on background (chronic prostatouretritis, chronic prostatitis) received course of anti inflam matory treatment (1st stage). Patients under observation received 2nd stage of treatment – therapy, which stimulates spermatogenesis. Those were divided according to the principle of the treatment: 1st group, control (n=30) – monotherapy by vitamin E 100 mg 3 times per day over 90 days, 2nd group, main (n=30) – monotherapy by Epadol neo 1 capsule 2 times per day over 90 days.

Results. Analyzing data of therapy after treatment, we can see quite pronounced tendency to increasing of capacity of ejaculate, especially in patients of 2nd main group, which received Epadol neo. Also the concentration of spermatozoons in 1 milliliter reliably increased in all patients after held course of treatment. But in 2nd group of patients this index is much better, which shows on notable effect of increasing of fertility of prescribed medication. Percentage of actively moving and alive spermatozoons also reliably increased, but again this index is much better in patients of 2nd main group.

Conclusion. According to the results of the treatment, prescription of Epadol neo 1 capsule 2 times per day during 3 months helps to strengthen fertility in men with excretory toxic infertility with chron ic inflammatory diseases of the genitourinary system on background (chronic prostatouretritis, chronic prostatitis) and allows to reach pos itive results of the treatment and achieve stable clinical effect and may be recommended for widespread use.


Keywords


excretory-toxic infertility; Epadol Neo; treatment

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