DOI: https://doi.org/10.30841/2307-5090.3 (58).2016.104160

Experience of hyaluronic acid in men with chronic pelvic pain syndrome on the background of interstitial cystitis

І. І. Горпинченко, В. В. Спиридоненко

Abstract


In SI «Institute of Urology of NAMS of Ukraine» was observed 61 male with chronic pelvic pain syndrome (CPPS) associated with interstitial cystitis (IC). The first group (n=30) consisted of persons with this diagnosis, treated with intravesical hyaluronic acid (HA, Instilan ® drug production «Yuri Farm», Ukraine), a course of 6 instillations - in the first month 1 time per week, then 1 times month No 2. The control group (n=31) were similar to patients treated with intravesical DMSO mixture (20% – 10 ml) of 2% – 10,0 ml of lidocaine, 1 time per week, the course of 12 instillations. The average age of study 46,2±1,1 years, history of disease duration – 2,2±0,4 years.
It has been found that the use of HA as intravesical instillation in men with ITs it is a highly effective method of treatment. Comparison of the results of treatment of established development of persistent remission in patients with IC in the application of GC (62,2%), which was almost 1.8 times better than the results of a similar therapy with DMSO with lidocaine (34,8%). The effectiveness of therapy GK manifested in symptoms regression in terms of 6 and 12 months by 37,9% and 47,2% (in the control – by 25,9% and 28,7%, respectively; p<0,05). Therapy with GC (Instilan ®) characterized by a lower frequency of refusal of treatment by patients – 3,3%, in contrast to the individual group II (25,8%), where the risk of adverse events at the time of treatment was significantly higher.


Keywords


interstitial cystitis in men; hyaluronic acid; intravesical instillations

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